Serum metabolic profiling of targeted bile acids reveals potentially novel biomarkers for primary biliary cholangitis and autoimmune hepatitis

Table 7 Changes of the serum bile acid profile between primary biliary cirrhosis and autoimmune hepatitis in different grade of Child-Pugh

	AIH-A/PBC/A	AIH-B/PBC-B	AIH-A/AIH-B	PBC-A/PBC-B	PBC-B/PBC-C	PBC-A/PBC-C	AIH-A/control	AIH-B/control	PBC-A/control	PBC-B/control	PBC-C/control
	P value	P value	P value	P value	P value	P value	P value	P value	P value	P value	P value
CA	0.75	0.34	0.24	0.67	0.82	0.50	< 0.001	< 0.001	< 0.001	< 0.001	0.03
GCA	0.79	0.03	< 0.001	0.07	0.43	0.02	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
TCA	0.79	0.03	< 0.001	0.0522	0.71	0.0567	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
UDCA	0.77	0.26	0.07	0.70	0.30	0.38	< 0.001	0.52	<0.001	0.05	< 0.001
GUDCA	0.60	0.33	0.40	0.58	0.21	0.06	< 0.001	0.13	< 0.001	< 0.001	< 0.001
TUDCA	0.97	0.22	1.00	0.10	0.29	0.02	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
CDCA	0.26	0.09	0.07	0.30	0.44	0.78	< 0.001	0.47	< 0.001	< 0.001	< 0.001
GCDCA	0.89	0.19	0.01	0.06	0.17	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
TCDCA	0.82	0.20	0.31	0.34	0.92	0.26	0.05	0.48	0.02	0.01	0.04
GCDCS	0.33	0.04	< 0.001	0.15	0.24	0.01	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
DCA	0.71	0.26	0.02	0.13	0.66	0.38	0.24	0.01	0.64	0.21	0.45
GDCA	0.50	0.08	0.09	0.37	0.09	0.11	< 0.001	< 0.001	< 0.001	0.01	< 0.001
TDCA	0.69	0.03	< 0.001	0.01	0.33	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
LCA	0.29	0.13	0.57	0.82	0.24	0.33	0.08	0.51	< 0.001	< 0.001	< 0.001
TLCA	0.07	0.88	0.05	0.13	0.74	0.29	0.01	< 0.001	< 0.001	< 0.001	< 0.001
CDCA/CA	0.46	0.04	0.04	0.66	0.50	0.27	< 0.001	< 0.001	< 0.001	0.06	0.26
Primary bile acid	0.75	0.81	0.96	0.42	0.70	0.96	< 0.001	0.02	< 0.001	< 0.001	< 0.001
Secondary bile acid	0.92	0.80	0.20	0.33	0.20	0.45	< 0.001	0.45	< 0.001	0.15	< 0.001
Secondary/primary	0.61	0.99	0.32	0.27	0.23	0.44	0.30	0.05	0.06	0.01	0.78
Secondary bile acid	0.89	0.91	0.08	0.05	0.24	0.79	0.13	0.08	0.09	0.12	0.35
Glycoconjugates	0.53	0.16	< 0.001	0.21	0.16	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Tauroconjugted	0.48	0.08	< 0.001	0.02	0.42	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Glyco/tauro	0.21	0.56	0.23	0.63	0.07	0.18	0.01	< 0.001	< 0.001	< 0.001	< 0.001
Total BA	0.62	0.72	0.05	0.26	0.19	0.01	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

Bile acid (BA) levels are expressed in log10 concentrations. Statistically significant differences in BA concentrations between controls and patients were determined by the rank sums Mann-Whitney test. CA: Cholic acid; CDCA: Chenodeoxycholic acid; DCA: Deoxycholic acid; GCA: Glycocholic acid; GCDCA: Glycochenodeoxycholic acid; GCDCS: Glycochenodeoxycholic sulfate; GDCA: Glycodeoxycholic acid; GUDCA: Glycoursodeoxycholic acid; LCA: Lithocholic acid; TCA: Taurocholic acid; TCDCA: Taurochenodeoxycholic acid; TDCA: Taurodeoxycholic acid; TLCA: Taurolithocholic acid; TUDCA: Tauroursodeoxycholic acid; UDCA: Ursodeoxycholic acid; PBA: Primary bile acid; PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis.