Serum metabolic profiling of targeted bile acids reveals potentially novel biomarkers for primary biliary cholangitis and autoimmune hepatitis

doi:10.3748/wjg.v28.i39.5764

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World Journal of Gastroenterology

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World J Gastroenterol. Oct 21, 2022; 28(39): 5764-5783
Published online Oct 21, 2022. doi: 10.3748/wjg.v28.i39.5764

Table 5 Changes of the serum bile acid profile between primary biliary cirrhosis, autoimmune hepatitis and controls

	AIH (mean ± SD)	PBC (mean ± SD)	Control (mean ± SD)	PBC/AIH	AIH/control	PBC/control
	AIH (mean ± SD)	PBC (mean ± SD)	Control (mean ± SD)	P value	P value	P value
CA	2.38 ± 0.69	2.26 ± 0.85	1.60 ± 0.51	0.53	< 0.001^b	< 0.001^a
GCA	3.00 ± 1.02	2.91 ± 0.91	1.33 ± 0.50	0.69	< 0.001^b	< 0.001^a
TCA	2.12 ± 1.23	2.12 ± 0.93	0.03 ± 0.46	0.99	< 0.001^b	< 0.001^a
UDCA	2.41 ± 1.03	2.60 ± 1.05	2.05 ± 0.36	0.62	0.2	0.01^a
GUDCA	2.59 ± 1.17	3.04 ± 1.14	1.64 ± 0.50	0.09	< 0.001^b	< 0.001^a
TUDCA	1.48 ± 1.07	1.84 ± 1.09	0.13 ± 0.25	0.15	< 0.001^b	< 0.001^a
CDCA	2.88 ± 0.39	3.07 ± 0.48	2.63 ± 0.38	0.046^c	0.01^b	< 0.001^a
GCDCA	3.78 ± 0.80	3.79 ± 0.67	2.93 ± 0.33	0.96	< 0.001^b	< 0.001^a
TCDCA	2.73 ± 0.40	2.84 ± 0.44	2.49 ± 0.57	0.27	0.09	0.004^a
GCDCS	2.39 ± 0.82	2.42 ± 0.70	1.08 ± 0.39	0.95	< 0.001^b	< 0.001^a
DCA	2.76 ± 0.35	2.75 ± 0.40	2.76 ± 0.18	0.87	0.7	0.59
GDCA	3.18 ± 0.58	3.14 ± 0.53	2.64 ± 0.32	0.8	< 0.001^b	< 0.001^a
TDCA	3.32 ± 0.64	3.16 ± 0.50	2.57 ± 0.19	0.33	< 0.001^b	< 0.001^a
LCA	0.94 ± 0.68	1.28 ± 0.66	0.72 ± 0.43	0.04^c	0.14	< 0.001^a
TLCA	0.30 ± 0.41	0.48 ± 0.47	0.02 ± 0.06	0.07	< 0.001^b	< 0.001^a
LCA + TLCA	1.25 ± 0.18	1.75 ± 0.14	0.74 ± 0.07	0.034^c	0.031^b	< 0.001^a
CDCA/CA	1.30 ± 0.35	1.56 ± 0.65	1.74 ± 0.42	0.26	< 0.001^b	< 0.001^a
pBA	3.11 ± 0.45	3.17 ± 0.51	2.67 ± 0.38	0.98	< 0.001^b	< 0.001^a
sBA	3.14 ± 0.52	3.19 ± 0.61	2.87 ± 0.17	0.75	0.003^b	0.002^a
pBA/sBA	1.02 ± 0.18	1.01 ± 0.17	1.08 ± 0.13	0.85	0.087	< 0.001
sBA	2.77 ± 0.35	2.79 ± 0.40	2.77 ± 0.18	0.81	0.02^b	0.003^a
G-BA	4.14 ± 0.70	4.12 ± 0.64	3.16 ± 0.31	0.97	< 0.001^b	< 0.001^a
T-BA	3.58 ± 0.54	3.47 ± 0.46	2.89 ± 0.27	0.34	< 0.001^b	< 0.001^a
G-BA/T-BA	0.55 ± 0.34	0.65 ± 0.34	0.27 ± 0.30	0.25	< 0.001^b	< 0.001^a
total BA	36.31 ± 6.00	37.69 ± 7.40	24.80 ± 3.12	0.41	< 0.001^b	0.026^a

^aP < 0.05 Primary biliary cirrhosis (PBC) vs control.

^bP < 0.05 Autoimmune hepatitis (AIH) vs control.

^cP < 0.05 PBC vs AIH

Bile acid (BA) levels are expressed in log10 concentrations. Statistically significant differences in BA concentrations between controls and patients were determined by the rank sums Mann-Whitney test. CA: Cholic acid; CDCA: Chenodeoxycholic acid; DCA: Deoxycholic acid; GCA: Glycocholic acid; GCDCA: Glycochenodeoxycholic acid; GCDCS: Glycochenodeoxycholic sulfate; GDCA: Glycodeoxycholic acid; GUDCA: Glycoursodeoxycholic acid; LCA: Lithocholic acid; TCA: Taurocholic acid; TCDCA: Taurochenodeoxycholic acid; TDCA: Taurodeoxycholic acid; TLCA: Taurolithocholic acid; TUDCA: Tauroursodeoxycholic acid; UDCA: Ursodeoxycholic acid; PBA: Primary bile acid; PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis.

Citation: Ma ZH, Wang XM, Wu RH, Hao DL, Sun LC, Li P, Niu JQ. Serum metabolic profiling of targeted bile acids reveals potentially novel biomarkers for primary biliary cholangitis and autoimmune hepatitis. World J Gastroenterol 2022; 28(39): 5764-5783
URL: https://www.wjgnet.com/1007-9327/full/v28/i39/5764.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i39.5764