Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease

doi:10.3748/wjg.v28.i38.5636

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Oct 14, 2022 (publication date) through Jan 3, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2022; 28(38): 5636-5647
Published online Oct 14, 2022. doi: 10.3748/wjg.v28.i38.5636

Table 3 Results of indirect and direct markers of liver fibrosis together with hematological markers in examined patients

Parameter (reference range)	ALC				MAFLD				Controls
Parameter (reference range)	mean ± SD	Median	Min	Max	mean ± SD	Median	Min	Max	mean ± SD	Median	Min	Max
RDW (11%-15%)	17.27 ± 3.26	16.7^d	12.2	27.9	14.25 ± 2.52	13.85^a	4.2	25	13.45 ± 1.1	13.4	11.1	15
RPR	0.26 ± 0.37	0.18^d	0.04	3.55	0.06 ± 0.02	0.06^d	0.02	0.18	0.05 ± 0.01	0.05	0.03	0.08
RLR	19.14 ± 12.27	15.73^d	1.6	79.23	10.89 ± 8.55	8.13^d	0.66	60	7.09 ± 2.48	6.24	3.38	12.5
FIB-4	11.67 ± 25.46	6.34^d	0.69	287.59	1.92 ± 1.63	1.57^d	0.23	11.58	0.85 ± 0.54	0.71	0.28	3.27
GPR	15.73 ± 28.54	6.65^d	0.18	188.71	2.76 ± 5.57	0.54^d	0.13	35.41	0.25 ± 0.1	0.24	0.06	0.63
PICP (ng/mL)	63.32 ± 31.53	60.53	6.15	161.12	52.14 ± 27.56	46.08	10.10	147.27	58.26 ± 37.39	44.18	0	202.89
PIIINP (ng/mL)	9.28 ± 4.33	8.4^b	2.43	28.65	11.41 ± 3.99	11.00	2.18	25.35	11.07 ± 5.61	10.25	4.35	43.63
PDGF-AB (pg/mL)	18280.47 ± 8061.06	17343.71^c	1925.68	42823.84	26858.68 ± 7335.09	26682.83	10821.02	49808.07	23579.28 ± 10068.8	25623.2	1638.2	47758.7
TGF-α (pg/mL)	24 ± 45.33	13.77^d	0.872	507.09	17.89 ± 19.18	12.09^d	1.39	142.63	28.44 ± 17.21	24.59	1.31	93.55
Laminin (ng/mL)	976.34 ± 705.29	832.06^a	101.933	3301.00	48 ± 230.24	375.23^d	72.87	1335.92	718.24 ± 386.1	663.27	140.88	1813.88

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

^dP < 0.0001.

ALC: Alcoholic liver cirrhosis; MAFLD: Metabolic associated fatty liver disease; Min: Minimum; Max: Maximum; AAR: Aspartate transaminase to alkaline transaminase ratio; APRI: Aspartate transaminase to platelet ratio index; FIB-4: Fibrosis-4; GPR: Gamma-glutamyl transpeptidase to platelet ratio; PICP: Procollagen I carboxyterminal propeptide; PIIINP: Procollagen III aminoterminal propeptide; PDGF-AB: Platelet-derived growth factor AB; TGF-α: Transforming growth factor-α; RDW: Red blood cell distribution width; RPR: Red blood cell distribution width-to-platelet ratio; RLR: Red blood cell distribution width-to-lymphocyte ratio.

Citation: Michalak A, Guz M, Kozicka J, Cybulski M, Jeleniewicz W, Lach T, Cichoż-Lach H. Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease. World J Gastroenterol 2022; 28(38): 5636-5647
URL: https://www.wjgnet.com/1007-9327/full/v28/i38/5636.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i38.5636