Clearance of the liver remnant predicts short-term outcome in patients undergoing resection of hepatocellular carcinoma

Table 4 Predictive factors for morbidity (Clavien–Dindo classification ≥ IIIa)

	Univariate analysis			Multivariate analysis
	P	OR	95%CI	P	OR	95%CI
Age (yr)	0.68	1.01	0.96-1.06
Gender (male : female)	0.69	0.80	0.27-2.36
Child–Pugh class	0.89	1.09	0.29-2.91
PT-INR	0.97	1.03	0.09-11.6
AST	0.27	0.99	0.98-1.00
ALT	0.11	0.99	0.98-1.00
Cholinesterase	0.58	1.00	0.99-1.01
ALBI score	0.02	3.57	1.19-10.7	0.790	1.22	0.286-5.19
Operation time	0.01	1.01	1.00-1.01	0.166	1.004	0.991-1.015
Intraoperative blood loss	0.001	1.0006	1.0002-1.001	0.005	1.0005	1.0002-1.0014
Hepatic clearance of the remnant liver	< 0.001	0.986	0.978-0.994	0.004	0.988	0.979-0.999
Functional volume of the remnant liver	0.003	0.998	0.996-0.999	0.329	0.99	0.997-1.00
LHL15	0.13	9.9	0.53-183	0.914	1.27	0.02-99.2

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; PT-INR: Prothrombin time international normalized ratio; ALBI: Albumin-bilirubin; LHL15: liver to heart-plus-liver radioactivity at 15 min; OR: Odds ratio; CI: Confidence interval.