Timing of endoscopic retrograde cholangiopancreatography in the treatment of acute cholangitis of different severity

Table 1 Characteristics of the patients

Patient characteristics	Total, n = 683	Time to ERCP divided by 24 h			Time to ERCP divided by 48 h
		ERCP ≤ 24 h, n = 134	ERCP > 24 h, n = 549	P value	ERCP ≤ 48 h, n = 314	ERCP > 48 h, n = 369	P value
Age in yr1	66 (53-78)	64 (56-75.5)	66 (52-78)	0.803	65 (54-79)	66 (51-79)	0.518
Male sex, n (%)	391 (57.2)	76 (56.7)	315 (57.4)	0.890	171 (54.5)	220 (59.6)	0.174
Body temperature in °C1	37.5 (36.8-38.4)	37.2 (36.7-38.1)	37.5 (36.9-38.5)	0.003	37.4 (36.8-38.28)	37.6 (36.9-38.5)	0.009
Abnormal WBC count2, n (%)	399 (58.4)	95 (70.9)	304 (55.4)	0.001	195 (62.1)	204 (55.3)	0.072
Platelet count as /µL1	198 (148-251)	205 (142-256)	196.5 (149-250)	0.806	195 (148-249.8)	200 (148-251.5)	0.844
AST in U/L1	150 (83-305)	175 (97-406)	145 (80-289)	0.063	164 (95-311)	139 (76-302)	0.08
ALT in U/L1	166 (82-300)	194 (118-337)	156 (79-292)	0.02	188 (101-311)	142 (69-277)	0.004
ALK-P in U/L1	205 (133-327)	198 (123-321)	209 (133-327)	0.486	190 (123-329)	211 (140-324)	0.208
Amylase in U/L1	65 (41-170) (n = 307)	68 (42-634) (n = 66)	65 (40-145) (n = 241)	0.126	68 (41-367) (n = 138)	62 (40-139) (n = 169)	0.118
Lipase in U/L1	37 (26-144) (n = 487)	46 (25-1297) (n = 97)	36 (26-99) (n = 390)	0.104	41 (26-339) (n = 232)	35 (26-76) (n = 255)	0.094
Bilirubin in mg/dL1	3.7 (2.3-6.3)	4.1 (2.6-5.8)	3.7 (2.3-6.3)	0.395	3.8 (2.4-6.2)	3.7 (2.3-6.5)	0.878
PT/INR1	1.1 (1.1-1.2)	1.1 (1.1-1.3)	1.1 (1.1-1.2)	0.685	1.1 (1.1-1.2)	1.2 (1.1-1.3)	0.001
Creatinine in mg/dL1	0.93 (0.73-1.24)	0.96 (0.78-1.45)	0.93 (0.72-1.20)	0.040	0.95 (0.75-1.28)	0.93 (0.72-1.21)	0.389
Albumin in g/dL1	3.56 (3.05-3.98) (n = 133)	3.83 (3.24-4.0) (n = 23)	3.48 (3.05-3.98) (n = 110)	0.218	3.69 (3.21-3.96) (n = 43)	3.46 (2.98-3.99) (n = 90)	0.334
Cardiovascular dysfunction, n (%)	29 (4.2)	15 (11.2)	14 (2.6)	< 0.001	18 (5.7)	11 (3.0)	0.076
Neurological disturbance, n (%)	35 (5.1)	9 (6.7)	26 (4.7)	0.351	16 (5.1)	19 (5.1)	0.975
Respiratory dysfunction, n (%)	48 (7)	19 (14.2)	29 (5.3)	< 0.001	24 (7.6)	24 (6.5)	0.562

¹Expressed as median (interquartile range).

²Abnormal WBC count is defined as WBC < 4000/µL or > 12000/µL.

ALK-P: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BT: Body temperature; ERCP: Endoscopic retrograde cholangiopancreatography; PT/INR: Prothrombin time/international normalized ratio; WBC: White blood cell count.