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©The Author(s) 2022.
World J Gastroenterol. Sep 28, 2022; 28(36): 5351-5363
Published online Sep 28, 2022. doi: 10.3748/wjg.v28.i36.5351
Published online Sep 28, 2022. doi: 10.3748/wjg.v28.i36.5351
Table 3 Univariate and multivariate analyses of factors associated with early extrahepatic recurrence
Univariate analysis | Multivariate analysis | |||
HR (95%CI) | P value | HR (95%CI) | P value | |
Serum albumin < 4.0 g/dL | 2.27 (1.56-3.29) | < 0.001 | 2.19 (1.45-3.31) | < 0.001 |
Serum ALP > 100 U/L | 1.76 (1.24-2.52) | 0.002 | 1.59 (1.08-2.32) | 0.018 |
ALBI grade ≥ 2 | 1.71 (1.12-2.59) | 0.012 | ||
Surgical margin involvement | 2.30 (1.07-4.93) | 0.032 | 2.53 (1.09-5.90) | 0.032 |
Pathological mUICC stage (III, IVa) | 2.94 (2.09-4.12) | < 0.001 | ||
Multiple tumors1 | 3.21 (1.57-6.56) | 0.002 | ||
Venous/lymphatic involvement2 | 2.98 (2.09-4.25) | < 0.001 | 1.90 (1.28-2.83) | 0.002 |
Serosa invasion | 2.86 (1.33-6.12) | 0.007 | ||
Bile duct invasion | 3.25 (1.20-8.83) | 0.020 | ||
Satellite nodule | 2.69 (1.83-3.94) | < 0.001 | 1.73 (1.14-2.63) | 0.011 |
Intrahepatic metastasis | 2.99 (1.10-8.09) | 0.032 | ||
Tumor necrosis | 3.18 (2.20-4.61) | <0.001 | 1.92 (1.29-2.79) | 0.001 |
Tumor hemorrhage | 1.81 (1.28-2.55) | 0.001 | ||
Sum of tumor size ≥ 7 cm | 3.25 (2.23-4.73) | < 0.001 | 1.84 (1.21-2.77) | 0.004 |
Macrovascular invasion | 2.48 (1.37-4.50) | 0.003 | 2.30 (1.24-4.26) | 0.008 |
Serum AFP > 1500 IU/mL | 1.99 (1.27-3.12) | 0.003 |
- Citation: Yoon JH, Choi SK, Cho SB, Kim HJ, Ko YS, Jun CH. Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection: A 15-year observational study. World J Gastroenterol 2022; 28(36): 5351-5363
- URL: https://www.wjgnet.com/1007-9327/full/v28/i36/5351.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i36.5351