Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for?

Table 1 Original Geboes score

Original Geboes score
Grade 0: Architectural changes	0.0 No abnormality; 0.1 Mild abnormality; 0.2 Mild/moderate diffuse or multifocal abnormalities; 0.3 Severe diffuse or multifocal abnormalities
Grade 1: Chronic inflammatory infiltrate	1.0 No increase; 1.1 Mild but unequivocal increase; 1.2 Moderate increase; 1.3 Marked increase
Grade 2A: Eosinophils in lamina propria	2A.0 No increase; 2A.1 Mild but unequivocal increase; 2A.2 Moderate increase; 2A.3 Marked increase
Grade 2B: Neutrophils in lamina propria	2B.0 No increase; 2B.1 Mild but unequivocal increase; 2B.2 Moderate increase; 2B.3 Marked increase
Grade 3: Neutrophils in epithelium	3.0 None; 3.1 < 5% crypts involved; 3.2 < 50% crypts involved; 3.3 > 50% crypts involved
Grade 4: Crypt destruction	4.0 None; 4.1 Probable: local excess of neutrophils in part of the crypts; 4.2 Probable: marked attenuation; 4.3 Unequivocal crypt destruction
Grade 5: Erosions and ulcerations	5.0 No erosion, ulceration or granulation tissue; 5.1 Recovering epithelium + adjacent inflammation; 5.2 Probable erosion: focally stripped; 5.3 Unequivocal erosion; 5.4 Ulcer or granulation tissue