Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1

Figure 6 Alcohol consumption regulated the mRNA expression of epithelial mesenchymal transformation-related markers and proinflammatory factors in colorectal cancer rats. The bars represent the mean ± SD (n = 8). A: Quantification of the mRNA levels of snail, focal adhesion kinase, fibronectin, N-cadherin, E-cadherin and special AT-rich sequence binding protein 1 in each group analyzed by quantitative real-time polymerase chain reaction; B: Tumor necrosis factor-α, interleukin-6 (IL-6) and IL-1β levels in each group. Compared with the non-alcohol group: ^bP < 0.01, ^aP < 0.05. SATB1: Special AT-rich sequence binding protein 1; FAK: Focal adhesion kinase; IL-1β: Interleukin-1β; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-α.