Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1

Figure 2 Alcohol consumption promotes colorectal cancer progression. A: Morphological view of colonic tumors; B: Average tumor number and tumor size in each group; C: Colon pathology of different groups (× 400); D: Pathology of colonic lymph node in different groups at the 24^th week (× 400); E: Methylene blue staining for aberrant crypt foci (ACF) in the sectioned rat colon (× 400); F: Bar graph of ACF with different crypt multiplicity. The bars represent the mean ± SD (n = 8). Compared with the non-alcohol group: ^bP < 0.01, ^aP < 0.05. ACF: Aberrant crypt foci.