Natural history and outcomes of patients with liver cirrhosis complicated by hepatic hydrothorax

Table 4 Multivariable Cox regression on patient survival to 12 mo

Model and variables	AHR (95%CI)	P value	Bootstrap CI	P value
Overall survival1
Age, per 5-yr increase	1.30 (1.01-1.67)	0.043	0.91-1.85	0.15
MELD score, per 5 points	1.53 (1.06-1.67)	0.025	0.89-2.66	0.13
Current smoking	8.65 (3.43-21.9)	< 0.001	2.54-29.5	0.001
Acute kidney injury	2.91 (1.21-6.97)	0.017	1.04-8.12	0.042
Transplant-free survival
Hepatic encephalopathy	2.00 (1.08-3.67)	0.030	0.93-4.28	0.078
MELD score, per 5 points	1.78 (1.38-2.29)	< 0.001	1.31-2.44	< 0.001
Current smoking	3.11 (1.49-6.52)	0.003	1.16-8.30	0.024
Acute kidney injury	2.18 (1.20-3.96)	0.011	1.10-4.31	0.026

¹Censored for liver transplantation.

MELD: Model for end-stage liver disease; AHR: Adjusted hazard ratio; CI: Confidence interval.