Gastrointestinal tumors in transplantation: Two case reports and review of literature

Table 3 Histopathological features, treatments, and outcome of 16 transplant patients with gastrointestinal stromal tumor

Ref.	Size (mm)	Mitotic count	Fletcher’s criteria	Joensuu’s criteria	Mutation identified	Resection	Initial adjuvant treatment	Second line treatment	Outcome
Agaimy and Wünsch[11]	35	< 5/50	Low	Low	Not described	Yes	No	Not described	Alive and relapse free at 68 mo
Agaimy and Wünsch[11]	230	14/50	High	High	Not described	Yes	No	Not described	Not described
Saidi et al[19]	25	1/50	Low	High	Not described	Yes	No	Not described	Alive and relapse free at 18 mo
Camargo et al[22]	50	5/50	Intermediate	High	Not described	Yes	No	Not described	Alive and relapse free at 20 mo
Tu et al[18]	45	2-3/50	Low	Low	PDGFRA exon 18 V824V	Yes	No	Not described	Alive and relapse free 24 mo
Mulder et al[12]	50	> 10/50	High	High	Not described	Yes	No	Imatinib 400 mg/d then 200 mg/d	Died 44 mo
Mrzljak et al[20]	10	1/50	Very low	Very low	Not described	Yes	No	No	Died 3 yr after from acute leukemia
Cimen et al[13]	150	14/50	High	High	KIT T574del	Yes	Imatinib 400 mg/d	Not described	Alive and relapse free at 12 mo
Cheung et al[14]	30	9/50	Intermediate	Intermediate	Not described	Yes	No	No	Died from pneumonia at 2 yr
Cheung et al[14]	Not described	Not described	Not described	Not described	Not described	No	Imatinib 400 mg/d for 1 yr	Switch CsA to sirolimus	Alive and relapse free at 10 yr
Patiño et al[15]	58	Not described	Intermediate or high	Intermediate of high	Not described	Yes	No	Imatinib 400 mg/d	Alive and relapse free/5 yr after imatinib initiation
Xie et al[21]	10	< 5/50	Very low	Very low	KIT exon 11	Yes	No	No	Not described
Elkabets et al[17]	31	Not described	Not described	Not described	Not described	Yes	No	No	Alive and relapse free at 40 mo
Takahashi et al[16]	110	20/50	High	High	KIT exon 11	Yes	Imatinib 400 mg/d reduced to 3000 mg/d	No	Alive and relapse free at 18 mo
Stammler et al	27	2/5	Low	Low	KIT exon 11	Yes	No	No	Alive and relapse free at 2 mo
Stammler et al	51	10/50	High	High	PDGFRA exon 18	Yes	No	Sunitinib then regorafenib then dasatinib	Died 56 mo later

CsA: Cyclosporine.