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©The Author(s) 2022.
World J Gastroenterol. Sep 14, 2022; 28(34): 4959-4972
Published online Sep 14, 2022. doi: 10.3748/wjg.v28.i34.4959
Published online Sep 14, 2022. doi: 10.3748/wjg.v28.i34.4959
Ref. | Study type | Total number of patients included in the study | Number of patients insufficient response to thiopurine or IM | Regimen of CAP | Rate of remission | Rate of steroid- free remission |
Cabriada et al[60], 2010 | Prospective study | 18 (SD) | 18 | GMA or LCAP (5-10 sessions, 1 session/wk) | 55% | |
Takayama et al[58], 2013 | Historical cohort study | 90 | 14 | GMA or LCAP (5-10 sessions, 1-2/wk) | 49% (total Pts), pre-use of IM had little effects on the response to therapy | |
Yokoyama et al[42], 2014 | Prospective Observation Study | 623 (for efficacy assessment) | 196 | LCAP (5-10 sessions, mean 8.4), intensive LCAP was performed in > 70% of Pts | 73% (Pts concomitantly treated with thiopurine), 71% (Pts treated without thiopurine), P = 0.623 | |
Imperiali et al[61], 2017 | Prospective multicenter study | 33 (SD) | 33 | GMA (5 sessions, 1 session/wk) | 36% | |
Yamamoto et al[37], 2018 | Retrospective study | 593 | 159 | GMA (5 sessions, 1 to 5 sessions/wk), 5 or 6 GMA were added in Pts who did not achieve clinical remission | 45% (Pts exposed to IM), 48% (Pts unexposed to IM), P = 0.61 | |
Dignass et al[36], 2016 | Single-arm, open-label, multicentre trial | 86 (SD) | 83 | GMA (5-10 sessions, 1 session/wk) | 40.3% | |
Ishiguro et al[62], 2020 | Multicenter cohort study | 102, SD or SR UC Pts were not included | 16 | GMA (mean number of GMA 9.9 sessions, 1-3 sessions/wk) | 56.3% (Pts concomitantly treated with IM), 53.5% (Pts treated without IM), P = 1.00 | |
Iizuka et al[59], 2021 | Retrospective study | 55 (SD: 33, SR: 21) | 12 | GMA or LCAP [5-20 sessions (mean 8.8), 1-2 sessions/wk (in principle)] | 66.7% (Pts concomitantly treated with thiopurine), 69.1% (all Pts), no significant differences | 41.7% (Pts concomitantly treated with thiopurine), 45.5% (all Pts), no significant differences |
- Citation: Iizuka M, Etou T, Sagara S. Efficacy of cytapheresis in patients with ulcerative colitis showing insufficient or lost response to biologic therapy. World J Gastroenterol 2022; 28(34): 4959-4972
- URL: https://www.wjgnet.com/1007-9327/full/v28/i34/4959.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i34.4959