Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms

doi:10.3748/wjg.v28.i34.4943

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Sep 14, 2022 (publication date) through Mar 7, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2022; 28(34): 4943-4958
Published online Sep 14, 2022. doi: 10.3748/wjg.v28.i34.4943

Table 1 2019 World Health Organization classification of neuroendocrine neoplasms of the gastrointestinal tract and hepatopancreatobiliary organs

NENs	Differentiation	Grade	Mitotic rate	Ki-67 index %
NET, G1	Well differentiated	Low	< 2	< 3
NET, G2	Well differentiated	Intermediate	2-20	3-20
NET, G3	Well differentiated	High	> 20	> 20
NEC, small cell type	Poorly differentiated	High	> 20	> 20
NEC, large cell type	Poorly differentiated	High	> 20	> 20
MiNEN	Well or poorly differentiated	Variable	Variable	Variable

NEN: Neuroendocrine neoplasm; NET: Neuroendocrine tumor; NEC: Neuroendocrine carcinoma; MiNEN: Mixed neuroendocrine-non-neuroendocrine neoplasm.

Citation: Iabichino G, Di Leo M, Arena M, Rubis Passoni GG, Morandi E, Turpini F, Viaggi P, Luigiano C, De Luca L. Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms. World J Gastroenterol 2022; 28(34): 4943-4958
URL: https://www.wjgnet.com/1007-9327/full/v28/i34/4943.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i34.4943