Chinese herbal formula shen-ling-bai-zhu-san to treat chronic gastritis: Clinical evidence and potential mechanisms

Table 3 Characteristics of included studies

Ref.	Study design	Sample size (E/C)	Gender (E/C) and age (yr)	Duration	Interventions		Period	Outcome measure	Balance report of baseline
					Control group	Experimental group
Yun[27], 2014	RCT	48 (24/24)	(13/11) (10/14); (34.96 ± 11. 39)/(34.08 ± 12.82)	Not mentioned	Rabeprazole enteric-coated capsule	Rabeprazole enteric-coated capsule + SLBZD	4 wk	Effective rate	P > 0.05
Chen et al[28], 2014	RCT	79 (40/39)	(24/16) (23/16); (42.6 ± 13.1)/43.5 ± 13.4	6-17 mo/6-19 mo	Triple therapy (clarithromycin sustained-release tablets + rabeprazole sodium capsule + metronidazole tablets)	Triple therapy + SLBZD	4 wk	Effective rate	P > 0.05
Chen et al[29], 2018	RCT	60 (30/30)	(14/16) (15/15); (55.45 ± 6.55)/(55.46 ± 6.44)	3-12 mo	Quadruple therapy (rabeprazole sodium capsule + amoxicillin + clarithromycin sustained-release tablets + biskalcitrate)	Quadruple therapy + SLBZD	8 wk	Effective rate; H. Pylori eradication; adverse event	P > 0.05
Du[30], 2017	RCT	48 (26/22)	(14/12) (12/10); (40.7 ± 6.1)/(41.2 ± 6.6)	7 mo-9 years/6 mo-8 years	Quadruple therapy (amoxicillin clavulanic potassium chewable tablets + metronidazole + omeprazole + compound bismuth aluminate capsule)	SLBZD	5 wk	Effective rate	P > 0.05
Gu[31], 2017	RCT	98 (49/49)	Not mentioned; 19-58	Not mentioned	Triple therapy (omeprazole + clarithromycin + amoxicillin)	Triple therapy + SLBZD	4 wk	Effective rate; H. Pylori eradication rate; adverse event	P > 0.05
Li et al[32], 2020	RCT	66 (33/33)	(19/14) (18/15); (58.54 ± 4.65)/(58.62 ± 4.57)	4-17 years/4-18 years	Triple therapy (mosapride tablet + polyzyme tablets + lansoprazole tablets)	Triple therapy + SLBZD	12 wk	Effective rate	P > 0.05
Tang[33], 2014	RCT	60 (30/30)	(16/14) (17/13); (22-46)/(23-52)	Not mentioned	Omeprazole enteric-coated capsules	Omeprazole Enteric-coated Capsules + SLBZD	8 wk	Effective rate	P > 0.05
Xia[34], 2015	RCT	300 (150/150)	Not mentioned; 18-85	Not mentioned	Omeprazole enteric-coated capsules	SLBZD	8 wk	Effective rate; recurrence rate; adverse event	P > 0.05
Xu et al[35], 2018	RCT	60 (30/30)	(17/13) (16/14); (55.6 ± 16.4)/(56.8 ± 14.9)	4-20 years/4-19 years	Triple therapy (mosapride tablet + polyzyme tablets + lansoprazole tablets)	Triple therapy+SLBZD	12 wk	Effective rate	P > 0.05
Zhang et al[36], 2020	RCT	68 (34/34)	(15/19) (17/17); (44.8 ± 5.0)/(45.2 ± 5.4)	1-12 years/2-14 years	Combination therapy (omeprazole + compound bismuth aluminate granules)	Combination therapy + SLBZD	8 wk	Effective rate; adverse events	P > 0.05
Zhao and Lin[37], 2010	RCT	80 (40/40)	(37/3) (38/2); (46.2 ± 6.7)/(44.2 ± 5.7)	2-7 years/2-8 years	No alcohol, famotidine	No alcohol, famotidine + SLBZD	4 wk	Effective rate;	P > 0.05
Zheng[38], 2014	RCT	92 (46/46)	(28/18) (30/16); ( 34 ± 5.34)/( 33 ± 5.76)	5 mo-6 years/7 mo-6 years	Triple therapy (amoxicillin dispersion tablet + omeprazole enteric-coated capsules + clarithromycin tablet)	SLBZD	4 wk	Effective rate; adverse events; recurrence rate	P > 0.05
Zhuang et al[39], 2019	RCT	106 (53/53)	(65/41); (46.20 ± 8.75)	1-11 years	Triple therapy (omeprazole enteric-coated tablets + clarithromycin dispersible tablets+amoxil capsule)	Triple therapy + SLBZD	4 wk	Effective rate; H. Pylori’s negative conversion rate	P > 0.05
Zou[40], 2015	RCT	170 (85/85)	(86/84); (40.9 ± 11.1)	Not mentioned	Triple therapy (amoxicillin + clarithromycin + omeprazole)	Triple therapy + SLBZD	8 wk	Effective rate; H. Pylori’s negative conversion rate; recurrence rate	P > 0.05

RCT: Randomized controlled trial; H. Pylori: Helicobacter pylori; SLBZS: Shen-ling-bai-zhu san.