Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer

doi:10.3748/wjg.v28.i33.4812

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Sep 7, 2022 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2022; 28(33): 4812-4822
Published online Sep 7, 2022. doi: 10.3748/wjg.v28.i33.4812

Table 3 The results of special examination of subjects with pancreatic ductal adenocarcinoma

No.	Sex	Age in yr	Blood samples				Pancreatic tissue
No.	Sex	Age in yr	HBsAg	Anti-HBc	Anti-HBs	HBV DNA, IU/mL	HBV DNA, IU/mL	pgRNA HBV, IU/mL	cccDNA, copies/cell × 10^-6	HBxAg	HBx-positive cells¹, %
1	M	50	Neg	Pos	Neg	Tnd	653	Tnd	257	Pos	3.9
2	F	58	Neg	Pos	Pos	Tnd	415	797	1440	Np	Np
3	M	60	Neg	Pos	Pos	Tnd	1183	Tnd	Tnd	Pos	3.7
4	M	61	Neg	Pos	Pos	Tnd	364	520	314	Pos	3.4
5	F	63	Neg	Pos	Pos	Tnd	Tnd	Tnd	Tnd	Neg	0
6	F	66	Neg	Pos	Pos	134	868	Np	Np	Np	Np
7	M	69	Neg	Pos	Pos	Tnd	610	Tnd	Tnd	Np	Np
8	M	69	Neg	Pos	Pos	Tnd	302	1428	1384	Np	Np
9	F	70	Neg	Pos	Pos	126	834	Tnd	1026	Pos	9.9

¹Data are shown as median values by several fields of vision.

HBsAg: Hepatitis B surface antigen; anti-HBc: Antibody to hepatitis B core antigen; anti-HBs: Antibody to hepatitis B surface antigen; pgRNA: Pregenomic RNA; cccDNA: Covalently closed circular DNA; HBxAg: Hepatitis B virus X antigen; Np: Not performed; Tnd: Target not detected; Neg: Negative; Pos: Positive; HBV: Hepatitis B virus; M: Male; F: Female.

Citation: Batskikh S, Morozov S, Dorofeev A, Borunova Z, Kostyushev D, Brezgin S, Kostyusheva A, Chulanov V. Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer. World J Gastroenterol 2022; 28(33): 4812-4822
URL: https://www.wjgnet.com/1007-9327/full/v28/i33/4812.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i33.4812