Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer

doi:10.3748/wjg.v28.i33.4744

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Sep 7, 2022 (publication date) through Oct 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2022; 28(33): 4744-4761
Published online Sep 7, 2022. doi: 10.3748/wjg.v28.i33.4744

Table 1 Characteristics of individual colorectal cancer subtypes

CMS1	CMS2	CMS3	CMS4
(MSI immune)	(Canonical)	(Metabolic)	(Mesenchymal)
CIMP high	CIN	CIN, CIMP low	CIN
Hypermethylation
SCNA-low	SCNA-high	SCNA-intermediate	SCNA-high
BRAF mutant		KRAS mutant
Activation of immune cells	WNT, MYC activation	Metabolic deregulation	TGF- activation
Worse survival after relapse	Superior survival after relapse		Worse relapse-free and overall survival

SCNA: Somatic copy number alteration; CIN: Chromosomal instability; CIMP: Methylation of the CpG island; TGF: Transforming growth factor.

Citation: Maslankova J, Vecurkovska I, Rabajdova M, Katuchova J, Kicka M, Gayova M, Katuch V. Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer. World J Gastroenterol 2022; 28(33): 4744-4761
URL: https://www.wjgnet.com/1007-9327/full/v28/i33/4744.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i33.4744