The mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway

Figure 1 Network construction. A: Venn diagram of the candidate targets in Yinchenhao decoction (YCHD) and obstructive jaundice (OJ); B: The Component-Target network. The blue circles refer to 123 putative targets of YCHD for the treatment of OJ. The red and purple diamonds represent YCHD and OJ, respectively. The green oval represents the chemical composition. The blue rectangle represents the target protein. The degree indicates the number of routes connected to this node in the network; C: The protein–protein interaction network. The size of the set node is proportional to the degree, and the larger the degree, the redder the color, indicating that the target interaction is higher. The key targets are protein kinase B, tumor protein 53, interleukin 6, vascular endothelial growth factor A, and caspase-3. They are the core targets of YCHD in treating OJ; D: The Gene Ontology enrichment analysis of involved biological processes; E: The Kyoto Encyclopedia of Genes and Genomics pathway enrichment analysis of putative targets; F: Component-target-signaling pathway network. The red hexagon represents the signaling pathway; the yellow hexagon represents the component; and the blue circle represents the target.