Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma

Figure 8 Effect of S50 combined H8 or KC7 intervention on target gene mRNA expression. A: Regulatory effect of S50 + H8 on expression of different genes under hypoxia condition; B: Effect of S50 + KC7 on expression of different genes. ^aP < 0.05 vs S50 + H8; ^bP < 0.01 vs S50 + H8; ^cP < 0.05 vs S50 + KC7; ^dP < 0.01 vs S50 + KC7. mTOR: Mammalian target of rapamycin; VEGF: Vascular endothlial growth factor; FoxP3: Forkhead box P3; PTEN: Phosphatase and tensin homolog deleted on chromosome ten.