Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

doi:10.3748/wjg.v28.i32.4649

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Aug 28, 2022; 28(32): 4649-4667
Published online Aug 28, 2022. doi: 10.3748/wjg.v28.i32.4649

Table 6 Univariate and multivariate analyses of prognostic factors associated with 5-year overall survival

Variables	N	Univariate		Multivariate
Variables	N	5-yr OS rate (%)	P value	HR (95%CI)	P value
Total	195
Sex
Male	128	87.9	0.3274
Female	67	85.3	0.3274
Age
< 65	77	89.7	0.4113
65	118	85.2	0.4113
Location
U	41	80.9	0.2629
M, L	154	88.6	0.2629
Tumor length (mm)
< 30	63	97.8	0.0020^a	3.010 (0.347-26.12)	0.3176
30	132	80.1	0.0020^a
Histological type
tub1, tub2, pap	96	88.3	0.4544
por, sig, muc	99	85.6	0.4544
Lymphatic invasion
Negative	110	96.1	0.0002^a	1.872 (0.549-6.384)	0.3166
Positive	85	75.7	0.0002^a
Venous invasion
Negative	131	90.6	0.0126^a	1.085 (0.476-2.472)	0.8469
Positive	64	79.3	0.0126^a
pT
pT1-2	137	95.9	< 0.0001^a	5.240 (1.807-15.20)	0.0023^c
pT3-4	58	65.5	< 0.0001^a
pN
pN0	139	94.1	< 0.0001^a	2.148 (0.695-6.643)	0.1844
pN1-3	56	67.6	< 0.0001^a
IHC score
< 1.3	137	89.6	0.0104^a	2.318 (1.016-5.288)	0.0457^c
1.3	58	73.9	0.0104^a

^aP < 0.05: Log-rank test.

^cP < 0.05: Cox hazard regression analysis.

CI: Confidence interval; HR: Hazard ratio; IHC: Immunohistochemical; L: Lower; M: Middle; muc: Mucinous adenocarcinoma; OS: Overall survival; pap: Papillary adenocarcinoma; pN: Pathological N stage; por: Poorly differentiated adenocarcinoma; pT: Pathological T stage; sig: Signet-ring cell carcinoma; tub: Tubular adenocarcinoma; U: Upper.

Citation: Fukami T, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Morinaga Y, Konishi E, Otsuji E. Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer. World J Gastroenterol 2022; 28(32): 4649-4667
URL: https://www.wjgnet.com/1007-9327/full/v28/i32/4649.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i32.4649