Anti-tumour activity and toxicological studies of combination treatment of Orthosiphon stamineus and gemcitabine on pancreatic xenograft model

Table 3 Effect of C5EOSEW5050ESA and gemcitabine alone or in combination on mouse key organ weight

No.	Group	Organ weight, g			P value
		Liver	Kidney	Spleen
1	Untreated	1.7 ± 0.22	0.47 ± 0.06	0.11 ± 0.03	-
2	Gemcitabine (10 mg/kg per 3 d)	1.7 ± 0.23	0.46 ± 0.06	0.10 ± 0.03	NS
3	O.s (200 mg/kg per day)	1.67 ± 0.23	0.47 ± 0.06	0.11 ± 0.03	NS
4	O.s (200 mg/kg per day) and gemcitabine (10 mg/kg per 3 d) combination	1.31 ± 0.25	0.41 ± 0.08	0.07 ± 0.03	NS
5	O.s (400 mg/kg per day)	1.37 ± 0.35	0.41 ± 0.09	0.24 ± 0.02	NS
6	O.s (400 mg/kg per day) and gemcitabine (10 mg/kg per 3 d) combination	1.43 ± 0.19	0.43 ± 0.09	0.08 ± 0.02	NS

Data are presented as mean ± SD (n = 6) (NS: Not significant compared to the untreated group, P > 0.05). No statistical difference was also observed among all treatment groups using two-way ANOVA and Tukey’s honest significant difference posthoc test. O.s: Orthosiphon stamineus.