Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats

Figure 1 Effects of duodenal-jejunal bypass on metabolic parameters. A: Body weight of rats; B: Food intake of rats; C: Fasting blood glucose of rats; D: Oral glucose tolerance test (OGTT) at 2 wk after operation; E: OGTT at 8 wk after operation; F: Area under the curve (AUC) of OGTT at 2 and 8 wk after operation; G: Intraperitoneal pyruvate tolerance test (ipPTT) at 2 wk after operation; H: ipPTT at 8 wk after operation; I: AUC_ipPTT at 2 and 8 wk after operation. ^cP < 0.001 duodenal-jejunal bypass (DJB) vs sham group by the Student’s t-test or post-hoc Bonferroni’s multiple comparison test. ^dP < 0.001, DJB vs sham group by mixed model ANOVA. AUC_OGTT: Area under the curve of oral glucose tolerance test; AUC_ipPTT: Area under the curve of intraperitoneal pyruvate tolerance test; OGTT: Oral glucose tolerance test; ipPTT: Intraperitoneal pyruvate tolerance test; DJB: Duodenal-jejunal bypass.