Simple cholecystectomy is an adequate treatment for grade I T1bN0M0 gallbladder carcinoma: Evidence from 528 patients

Table 2 Multivariate Cox proportional hazards model for 10-year overall survival and disease-specific survival in 528 patients with T1b gallbladder cancer

Variable	10-year overall survival		10-year disease-specific survival
	HR (95%CI)	P value	HR (95%CI)	P value
Age, yr
< 70	Referent		Referent
≥ 70	2.03 (1.57-2.63)	< 0.001	NA	NA
Gender
Male	Referent		Referent
Female	0.71 (0.55-0.91)	0.007	0.62 (0.45-0.87)	0.005
Grade
Grade I	Referent		Referent
Grade II	NA	NA	1.21 (0.83-1.76)	0.321
Grade III, IV	NA	NA	2.20 (1.43-3.38)	< 0.001
Histological type
Adenocarcinoma	Referent		Referent
Papillary	NA	NA	NA	NA
Other	NA	NA	NA	NA
Surgery
SC	Referent		Referent
SC + LN	0.71 (0.53-0.95)	0.020	0.56 (0.37-0.83)	0.004
RC	0.54 (0.32-0.89)	0.015	0.49 (0.27-0.92)	0.025

SC: Simple cholecystectomy; LN: Lymph node resection; RC: Radical cholecystectomy; N: Number; HR: Hazard ratio; CI: Confidence interval; NA: Not available.