Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

Table 4 Association of risk factors with acute-on-chronic liver failure development during hospitalization using logistic regression in univariate and multivariate analysis

	OR	95%CI	P value
Univariable logistic regression
Demographic data
Age	0.96	0.21-6.18	0.96
Male	2.89	0.83-9.17	0.08
Etiology	0.90	0.43-1.70	0.76
Acute decompensation events
Overt ascites	0.92	0.3-3.14	0.89
Gastrointestinal bleeding	0.74	0.11-2.9	0.7
Bacterial infection	2.22	0.69-6.95	0.17
Hepatic encephalopathy	3.6	0.51-15.95	0.13
Laboratory data
Total bilirubin	1.68	1.14-2.61	0.012
International normalized ratio	6.53	1.9-28.55	0.006
Creatinine	0.85	0.51-1.87	0.6
Blood urea nitrogen	1.52	0.84-2.63	0.12
Albumin	0.44	0.07-3.19	0.4
ALT	1.25	0.85-1.82	0.24
AST	1.14	0.73-1.75	0.55
White blood cells	0.88	0.45-1.75	0.72
Hemoglobin	0.39	0.11-1.5	0.16
K	1.53	0.13-18.28	0.74
Sodium	0	0-288.55	0.29
Neutrophil-lymphocyte ratio	1.37	0.84-2.23	0.21
ALP	1.15	0.59-2.27	0.7
GGT	0.86	0.54-1.34	0.52
Multivariable logistic regression
Male	3.24	0.84-11.63	0.07
TB	1.56	1.03-2.47	0.046
INR	4.31	1.15-21.70	0.048

Variables with P < 0.1 in univariate analysis were selected into multivariate analysis. Acute-on-chronic liver failure diagnosed on admission was excluded from the analysis. Continuous variables were log transformed before entering the model (base 2). ALT: Alanine transaminase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase; OR: Odds ratio; CI: Confidence interval; TB: Total bilirubin; INR: International normalized ratio.