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©The Author(s) 2022.
World J Gastroenterol. Aug 21, 2022; 28(31): 4417-4430
Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4417
Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4417
Table 2 Characteristics of autoimmune liver disease patients with acute-on-chronic liver failure according to etiology
Variable | PBC | AIH | PBC/AIH | Others | P value |
n = 14 | n = 10 | n = 7 | n = 3 | ||
Demographics | |||||
Age, median (IQR) | 55.34 (48.88, 58.96) | 55.94 (50.00, 64.01) | 53.46 (47.97, 63.46) | 50.85 (46.87, 58.00) | 0.88 |
Male, no. (%) | 6 (42.9) | 1 (10.0) | 0 (0.0) | 2 (66.7) | 0.04 |
AD, no. (%) | |||||
Bacterial infection | 7 (50.0) | 3 (30.0) | 6 (85.7) | 2 (66.7) | 0.14 |
Ascites | 9 (64.3) | 6 (60.0) | 5 (71.4) | 3 (100.0) | 0.61 |
Gastrointestinal bleeding | 1 (7.1) | 1 (10.0) | 0 (0.0) | 1 (33.3) | 0.39 |
Hepatic encephalopathy | 4 (28.6) | 3 (30.0) | 4 (57.1) | 2 (66.7) | 0.40 |
Jaundice | 10 (71.4) | 9 (90.0) | 6 (85.7) | 2 (66.7) | 0.64 |
Laboratory results, median (IQR) | |||||
TB, mg/dL | 16.78 (4.79, 27.10) | 12.56 (8.94, 17.64) | 23.60 (14.64, 27.52) | 14.56 (8.94, 19.29) | 0.71 |
INR | 1.57 (1.34, 1.77) | 2.64 (1.67, 2.80) | 1.49 (1.44, 2.31) | 1.50 (1.47, 1.97) | 0.35 |
Creatinine, mg/dL | 0.83 (0.79, 2.01) | 0.58 (0.50, 0.74) | 0.79 (0.75, 0.84) | 0.68 (0.36, 1.46) | 0.08 |
Blood urea nitrogen, mmol/L | 12.05 (6.04, 20.65) | 5.40 (2.74, 8.12) | 7.70 (7.20, 9.25) | 8.73 (6.92, 21.00) | 0.09 |
White blood cell, 109/L | 5.55 (3.62, 10.19) | 4.57 (3.13, 5.34) | 8.82 (6.55, 16.27) | 6.71 (4.91, 9.37) | 0.08 |
Neutrophil-lymphocyte ratio | 4.55 (3.78, 5.84) | 1.80 (1.06, 4.40) | 7.64 (5.66, 12.77) | 5.40 (4.86, 6.30) | 0.05 |
Albumin, g/L | 28.90 (26.75, 33.72) | 27.80 (25.38, 31.48) | 27.20 (25.05, 28.60) | 27.40 (25.00, 31.15) | 0.60 |
ALT, IU/L | 105.15 (33.30, 186.90) | 59.05 (38.65, 99.47) | 113.90 (102.60, 204.10) | 69.90 (57.55, 146.65) | 0.37 |
AST, IU/L | 121.50 (62.72, 182.23) | 99.45 (61.10, 172.75) | 153.00 (111.65, 238.05) | 34.20 (30.30, 85.15) | 0.33 |
Hemoglobin, g/L | 88.00 (40.75, 138.00) | 64.00 (33.00, 116.00) | 65.00 (46.00, 77.50) | 57.00 (55.20, 74.50) | 0.89 |
ALP, IU/L | 76.00 (69.00, 96.25) | 86.50 (82.00, 90.75) | 108.00 (89.00, 127.50) | 91.40 (65.80, 102.90) | 0.29 |
GGT, IU/L | 187.00 (111.25, 252.80) | 149.00 (125.65, 195.00) | 153.00 (109.00, 365.00) | NA (NA, NA) | 0.76 |
Pre-albumin, mg/L | 89.00 (52.00, 119.57) | 106.50 (45.25, 116.50) | 63.00 (58.70, 258.60) | NA (NA, NA) | 0.85 |
Albumin, g/L | 66.50 (54.60, 115.00) | 33.40 (23.55, 60.40) | 87.65 (60.35, 91.55) | NA (NA, NA) | 0.13 |
Score, median (IQR) | |||||
Child Turcotte Pugh | 9.50 (8.25, 10.75) | 12.00 (10.00, 12.75) | 11.00 (10.50, 12.50) | 11.00 (11.00, 12.50) | 0.04 |
MELD | 20.00 (18.00, 22.75) | 27.50 (18.50, 28.75) | 24.00 (22.00, 28.00) | 21.00 (20.50, 23.00) | 0.17 |
MELD Na | 21.00 (19.00, 25.00) | 26.50 (23.00, 28.75) | 29.00 (23.00, 32.00) | 41.00 (39.00, 41.50) | 0.12 |
CLIF SOFA | 7.00 (6.25, 8.00) | 7.00 (7.00, 8.00) | 8.00 (6.50, 9.00) | 9.00 (8.00, 10.00) | 0.32 |
- Citation: Shen ZX, Wu DD, Xia J, Wang XB, Zheng X, Huang Y, Li BL, Meng ZJ, Gao YH, Qian ZP, Liu F, Lu XB, Shang J, Yan HD, Zheng YB, Gu WY, Zhang Y, Wei JY, Tan WT, Hou YX, Zhang Q, Xiong Y, Zou CC, Chen J, Huang ZB, Jiang XH, Luo S, Chen YY, Gao N, Liu CY, Yuan W, Mei X, Li J, Li T, Zhou XY, Deng GH, Chen JJ, Ma X, Li H. Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China. World J Gastroenterol 2022; 28(31): 4417-4430
- URL: https://www.wjgnet.com/1007-9327/full/v28/i31/4417.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i31.4417