Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

Table 2 Characteristics of autoimmune liver disease patients with acute-on-chronic liver failure according to etiology

Variable	PBC	AIH	PBC/AIH	Others	P value
	n = 14	n = 10	n = 7	n = 3
Demographics
Age, median (IQR)	55.34 (48.88, 58.96)	55.94 (50.00, 64.01)	53.46 (47.97, 63.46)	50.85 (46.87, 58.00)	0.88
Male, no. (%)	6 (42.9)	1 (10.0)	0 (0.0)	2 (66.7)	0.04
AD, no. (%)
Bacterial infection	7 (50.0)	3 (30.0)	6 (85.7)	2 (66.7)	0.14
Ascites	9 (64.3)	6 (60.0)	5 (71.4)	3 (100.0)	0.61
Gastrointestinal bleeding	1 (7.1)	1 (10.0)	0 (0.0)	1 (33.3)	0.39
Hepatic encephalopathy	4 (28.6)	3 (30.0)	4 (57.1)	2 (66.7)	0.40
Jaundice	10 (71.4)	9 (90.0)	6 (85.7)	2 (66.7)	0.64
Laboratory results, median (IQR)
TB, mg/dL	16.78 (4.79, 27.10)	12.56 (8.94, 17.64)	23.60 (14.64, 27.52)	14.56 (8.94, 19.29)	0.71
INR	1.57 (1.34, 1.77)	2.64 (1.67, 2.80)	1.49 (1.44, 2.31)	1.50 (1.47, 1.97)	0.35
Creatinine, mg/dL	0.83 (0.79, 2.01)	0.58 (0.50, 0.74)	0.79 (0.75, 0.84)	0.68 (0.36, 1.46)	0.08
Blood urea nitrogen, mmol/L	12.05 (6.04, 20.65)	5.40 (2.74, 8.12)	7.70 (7.20, 9.25)	8.73 (6.92, 21.00)	0.09
White blood cell, 109/L	5.55 (3.62, 10.19)	4.57 (3.13, 5.34)	8.82 (6.55, 16.27)	6.71 (4.91, 9.37)	0.08
Neutrophil-lymphocyte ratio	4.55 (3.78, 5.84)	1.80 (1.06, 4.40)	7.64 (5.66, 12.77)	5.40 (4.86, 6.30)	0.05
Albumin, g/L	28.90 (26.75, 33.72)	27.80 (25.38, 31.48)	27.20 (25.05, 28.60)	27.40 (25.00, 31.15)	0.60
ALT, IU/L	105.15 (33.30, 186.90)	59.05 (38.65, 99.47)	113.90 (102.60, 204.10)	69.90 (57.55, 146.65)	0.37
AST, IU/L	121.50 (62.72, 182.23)	99.45 (61.10, 172.75)	153.00 (111.65, 238.05)	34.20 (30.30, 85.15)	0.33
Hemoglobin, g/L	88.00 (40.75, 138.00)	64.00 (33.00, 116.00)	65.00 (46.00, 77.50)	57.00 (55.20, 74.50)	0.89
ALP, IU/L	76.00 (69.00, 96.25)	86.50 (82.00, 90.75)	108.00 (89.00, 127.50)	91.40 (65.80, 102.90)	0.29
GGT, IU/L	187.00 (111.25, 252.80)	149.00 (125.65, 195.00)	153.00 (109.00, 365.00)	NA (NA, NA)	0.76
Pre-albumin, mg/L	89.00 (52.00, 119.57)	106.50 (45.25, 116.50)	63.00 (58.70, 258.60)	NA (NA, NA)	0.85
Albumin, g/L	66.50 (54.60, 115.00)	33.40 (23.55, 60.40)	87.65 (60.35, 91.55)	NA (NA, NA)	0.13
Score, median (IQR)
Child Turcotte Pugh	9.50 (8.25, 10.75)	12.00 (10.00, 12.75)	11.00 (10.50, 12.50)	11.00 (11.00, 12.50)	0.04
MELD	20.00 (18.00, 22.75)	27.50 (18.50, 28.75)	24.00 (22.00, 28.00)	21.00 (20.50, 23.00)	0.17
MELD Na	21.00 (19.00, 25.00)	26.50 (23.00, 28.75)	29.00 (23.00, 32.00)	41.00 (39.00, 41.50)	0.12
CLIF SOFA	7.00 (6.25, 8.00)	7.00 (7.00, 8.00)	8.00 (6.50, 9.00)	9.00 (8.00, 10.00)	0.32

PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis; PBC/AIH: Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome; AD: Acute decompensation; IQR: Interquartile range; TB: Total bilirubin; INR: International normalized ratio; ALT: Alanine transaminase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase; MELD: Model for end-stage liver disease; CLIF-SOFA: Chronic liver failure-sequential organ failure assessment; NA: Not available.