Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China

Table 1 Characteristics of autoimmune liver disease patients with cirrhosis and acute decompensation among different etiologies

	PBC	AIH	PBC/AIH	Others	P value
	n = 123	n = 69	n = 29	n = 21
Demographics
Age	56.00 (48.02, 63.83)	57.47 (49.33, 65.34)	52.62 (45.53, 60.85)	52.94 (41.15, 62.48)	0.28
Male, no. (%)	25 (20.3)	11 (15.9)	4 (13.8)	6 (28.6)	0.51
AD, no. (%)
Bacterial infection	34 (27.6)	21 (30.4)	13 (44.8)	8 (38.1)	0.30
Ascites	82 (66.7)	42 (60.9)	17 (58.6)	14 (66.7)	0.77
Gastrointestinal bleeding	27 (22.0)	11 (15.9)	4 (13.8)	2 (9.5)	0.42
Hepatic encephalopathy	10 (8.1)	4 (5.8)	6 (20.7)	3 (14.3)	0.11
Jaundice	61 (49.6)	35 (50.7)	19 (65.5)	9 (42.9)	0.38
Laboratory results, median (IQR)
TB, mg/dL	4.88 (1.60, 10.82)	5.15 (1.86, 11.14)	7.31 (3.04, 23.60)	4.88 (2.05, 11.72)	0.17
INR	1.29 (1.13, 1.52)	1.39 (1.23, 1.64)	1.39 (1.16, 1.49)	1.24 (1.15, 1.44)	0.044
Creatinine, mg/dL	0.65 (0.50, 0.88)	0.64 (0.51, 0.76)	0.67 (0.53, 0.79)	0.67 (0.45, 0.73)	0.51
Blood urea nitrogen, mmol/L	5.38 (3.70, 8.27)	4.73 (3.63, 5.95)	5.37 (3.90, 7.20)	4.50 (3.37, 6.60)	0.26
White blood cell, 109/L	4.39 (2.75, 6.34)	4.01 (2.81, 5.78)	6.85 (4.56, 11.76)	3.82 (3.10, 5.72)	0.001
Neutrophil-lymphocyte ratio	2.80 (1.73, 4.29)	2.00 (1.25, 3.25)	3.61 (3.01, 5.67)	2.89 (2.35, 4.86)	< 0.001
Platelet, 109/L	0.17 (0.11, 0.30)	0.15 (0.11, 0.25)	0.32 (0.14, 0.45)	0.12 (0.08, 0.30)	0.11
Albumin, g/L	30.30 (25.70, 33.70)	28.50 (25.70, 32.55)	29.90 (26.10, 33.80)	30.40 (28.45, 34.92)	0.262
ALT, IU/L	48.00 (24.50, 80.50)	59.00 (37.00, 116.00)	81.00 (61.00, 148.00)	57.90 (39.00, 85.40)	< 0.001
AST, IU/L	79.60 (48.40, 124.50)	87.00 (52.90, 187.00)	120.70 (79.00, 153.00)	90.00 (39.00, 148.00)	0.037
Hemoglobin, g/L	90.00 (68.00, 110.00)	99.00 (87.00, 119.00)	99.00 (85.00, 115.00)	98.00 (89.00, 112.00)	0.003
ALP, IU/L	208.50 (136.25, 313.00)	143.00 (105.74, 181.70)	175.50 (128.50, 243.00)	202.50 (133.50, 298.85)	< 0.001
GGT, IU/L	105.00 (51.23, 192.50)	86.63 (37.00, 126.00)	106.20 (58.70, 235.25)	122.70 (32.92, 220.22)	0.19
Pre-albumin, mg/L	78.30 (46.80, 113.90)	63.20 (40.93, 83.25)	77.30 (57.75, 97.80)	68.65 (54.75, 88.90)	0.25
Score, median (IQR)
Child Turcotte Pugh	9.00 (8.00, 10.00)	9.00 (8.00, 10.25)	10.00 (8.00, 11.00)	9.00 (8.00, 11.00)	0.58
MELD	11.00 (7.00, 17.00)	15.00 (11.00, 21.00)	18.00 (14.00, 23.00)	12.00 (10.00, 16.00)	< 0.001
MELD Na	14.00 (7.75, 19.00)	17.00 (12.00, 23.00)	20.50 (15.75, 25.00)	13.00 (10.00, 19.00)	< 0.001
CLIF SOFA	5.00 (3.00, 6.00)	5.00 (3.00, 6.00)	6.00 (3.00, 7.00)	5.00 (4.00, 6.00)	0.44

PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis; PBC/AIH: Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome; AD: Acute decompensation; IQR: Interquartile range; TB: Total bilirubin; INR: International normalized ratio; ALT: Alanine transaminase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transpeptidase; MELD: Model for end-stage liver disease; CLIF-SOFA: Chronic liver failure-sequential organ failure assessment.