Radiomics and nomogram of magnetic resonance imaging for preoperative prediction of microvascular invasion in small hepatocellular carcinoma

Table 4 Receiver operator characteristic curve analysis of radiomics scores with different sequences of magnetic resonance imaging for predict microvascular infiltration of small hepatocellular carcinoma

	T1WI	T2WI	DWI	AP	PVP	HBP
Training set
AUC	0.740	0.878	0.991	0.763	0.739	0.976
95%CI	0.661-0.808	0.814-0.926	0.958-0.999	0.695-0.823	0.661-0.807	0.940-0.991
P value	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
Sensitivity	77.08	82.98	95.74	71.43	56.25	89.83
Specificity	68.00	82.00	96.04	79.37	78.22	99.27
Testing set
AUC	0.776	0.813	0.971	0.788	0.790	0.979
95%CI	0.611-0.895	0.651-0.922	0.858-0.999	0.642-0.894	0.630-0.904	0.911-1.000
P value	0.0004	< 0.001	< 0.001	0.0014	0.0001	< 0.001
Sensitivity	91.67	58.33	100.00	64.29	84.62	100.00
Specificity	57.69	92.00	84.62	93.75	73.08	91.43
Validation Hospital B
AUC	0.834	0.825	0.816	0.810	0.847	0.970
95%CI	0.742-0.904	0.732-0.896	0.678-0.876	0.715-0.884	0.758-0.913	0.912-0.994
P value	< 0.001	< 0.001	0.0002	< 0.001	< 0.001	< 0.001
Sensitivity	63.64	95.45	71.43	57.14	54.55	95.45
Specificity	94.29	57.75	88.89	88.89	98.61	98.57
Validation Hospital C
AUC	0.766	0.761	0.801	0.824	0.833	0.803
95%CI	0.672-0.844	0.669-0.839	0.710-0.871	0.737-0.892	0.748-0.898	0.680-0.834
P value	0.0001	0.0003	< 0.001	< 0.001	< 0.001	0.007
Sensitivity	80.00	60.00	90.00	86.67	85.71	83.33
Specificity	70.45	89.01	68.89	68.54	72.83	77.67

T1WI: T1 weighted imaging; T2WI: T2 weighted imaging; DWI: Diffusion weighted imaging; AP: Arterial phase; PVP: Portal vein phase; HBP: Hepatobiliary phase; AUC: Area under the curve; 95%CI: 95% confidence interval.