Radiomics and nomogram of magnetic resonance imaging for preoperative prediction of microvascular invasion in small hepatocellular carcinoma

Table 3 Diagnostic performance of alpha-fetoprotein and radiologic features for assessing microvascular infiltration of small hepatocellular carcinoma by receiver operating characteristic curve analysis

	AFP	Tumor size	Nonsmooth tumor margin	Incomplete capsule	Peritumoral hypointensity
Hospital A
AUC	0.597	0.675	0.580	0.577	0.582
95%CI	0.528-0.662	0.609-0.736	0.512-0.646	0.509-0.643	0.514-0.648
P value	0.024	< 0.001	0.024	0.027	0.007
Sensitivity	34.92	70.31	42.19	39.06	26.56
Specificity	81.82	61.15	73.89	76.43	89.81
Hospital B
AUC	0.683	0.639	0.649	0.595	0.551
95%CI	0.577-0.777	0.553-0.735	0.544-0.745	0.489-0.695	0.445-0.654
P value	0.006	0.035	0.008	0.005	0.304
Sensitivity	63.64	81.82	71.43	95.45	22.73
Specificity	72.06	44.44	88.89	23.61	87.50
Hospital C
AUC	0.669	0.576	0.682	0.521	0.667
95%CI	0.568-0.760	0.473-0.675	0.581-0.771	0.419-0.622	0.565-0.758
P value	0.016	0.213	0.007	0.759	0.014
Sensitivity	87.50	68.75	62.50	62.50	50.00
Specificity	52.38	54.76	73.81	41.67	83.33

DeLong test for comparison of receiver operating characteristic curve. AFP: Alpha-fetoprotein; AUC: Area under the curve; 95%CI: 95% confidence interval.