Radiomics and nomogram of magnetic resonance imaging for preoperative prediction of microvascular invasion in small hepatocellular carcinoma

Table 2 Age, gender, alpha-fetoprotein and radiologic features of patients with small hepatocellular carcinoma and relationship with microvascular infiltration

	Hospital A (n = 221)			Hospital B (n = 94)			Hospital C (n = 100)
	Positive	Negative	P value	Positive	Negative	P value	Positive	Negative	P value
Age (yr)	50.9 ± 10.7	51.3 ± 10.9	0.840	51.7 ± 12.3	53.1 ± 10.1	0.597	53.5 ± 9.1	53.7 ± 11.0	0.958
Gender			0.593			0.443			0.259
Female	8	24		1	9		1	14
Male	56	133		21	63		15	70
AFP (ng/mL)	33.91 (range 1.40-25451.00)	22.52 (range 1-18929)	0.026	38.97 (range 1.90-6740.40)	5.43 (range 1.10-2018.79)	0.010	109.72 (range 0.80-2278.00)	24.41 (range 0.71-4587.00)	0.032
Size (cm)	2.34 ± 0.56	1.92 ± 0.67	0.036	2.43 ± 0.57	2.11 ± 0.66	0.047	2.47 ± 0.43	2.21 ± 0.64	0.054
Nonsmooth tumor margin			0.019			0.003			0.004
Absent	37	116		13	64		6	62
Present	27	41		9	8		10	22
Capsule			0.020			0.062			0.756
Absent	39	120		21	55		10	49
Present	25	37		25	17		6	35
Peritumoral hypointensity			0.002			0.304			0.007
Absent	47	141		17	63		70	8
Present	17	16		5	9		14	8

Size: Large tumor size; AFP: Alpha-fetoprotein; MVI: Microvascular infiltration.