Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe

doi:10.3748/wjg.v28.i31.4235

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Aug 21, 2022 (publication date) through Feb 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2022; 28(31): 4235-4248
Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4235

Table 2 Pancreatic juice and cyst fluid biomarkers, saliva biomarkers, urine biomarkers

Pancreatic juice and cyst fluid biomarkers
Mutant genes	Mucins	Interleukins	Methylated DNA markers
GNAS	MUC4	IL-1b	C13orf18
KRAS	MUC16	IL-5	FER1L4
TP53	MUC5AC	IL-8	BMP3
SMAD4
PIK3CA
PTEN
AKT1
Saliva biomarkers
Upregulated genes	Downregulated genes	LncRNA
MBD3L2	TK2	HOTAIR
KRAS	GLTSCR2	PVT1
STIM2	CDKL3
DMXL2	TPT1
ACRV1	DPM1
DMD
CABLES1
Urine biomarkers
Protein markers	MiRNA	Metabolites
REG1A	miR-143	CA19.9
TFF1	miR-204	Proline
LYVE1	miR-223	Sphingomyelin (d18:2, C17:0)
	miR-30e	Phosphatidylcholine
		Isocitrate
		Sphinganine-1-phosphate
		Histidine
		Pyruvate
		Sphingomyelin (d17:1, C18:0)

miRNA: MicroRNA; lncRNA: Long non-coding RNA.

Citation: Tonini V, Zanni M. Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe. World J Gastroenterol 2022; 28(31): 4235-4248
URL: https://www.wjgnet.com/1007-9327/full/v28/i31/4235.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i31.4235