Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe

doi:10.3748/wjg.v28.i31.4235

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Aug 21, 2022 (publication date) through Feb 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2022; 28(31): 4235-4248
Published online Aug 21, 2022. doi: 10.3748/wjg.v28.i31.4235

Table 1 Serum biomarkers

Carbohydrate antigens	CtDNA	miRNA	lncRNA	Metabolites
CA19-9	KRAS	miR21	SNHG15	3-hydroxybutyrate
CA125	ADAMTS1	miR25	HOTAIR	Lactate
CA72-4	BNC1	miR233	MALAT1	Glutamine
CA50	5-methylcytosine	miR216	MEG3	Alanine
CA242	5-hydroxymethylcytosine	miR-92-a-5p	H19	Valine
		miR-125b-3p	PVT1	Lysine
		miR-532e5p	HOTTIP	Citrate
		miR-663	HAND2-AS1	Histidine
		miR-1469	CTD-2033D15.2	Isoleucine
				Glutamate
				Acetone
				Dimethylamine
				N-succinyl-L-diaminopimelic
				PE (18:2)
Exosomal mRNA molecules	Exosomal small nucleolar RNA molecules	Exosome surfaceome	Exosomal long RNAs	Others
CCDC88A	SNORA14B	CLDN4	FGA	CTCs
ARF6	SNORA18	EPCAM	KRT19	ITGB5
Vav3	SNORA25	CD151	HIST1H2BK	PPY
WASF2	SNORA74A	LGAL53BP	ITIH2	ERBB3
	SNORD22	HIST2H2BE	MARCH2	SCAMP3
		HIST2H2BF	CLDN1	RET
			MAL2	5-NT
			TIMP1	CEACAM1
				S100A11

CtDNA: Circulation tumor DNA; miRNA: MicroRNA; lncRNA: Long non-coding RNA; CTC: Circulating tumor cells.

Citation: Tonini V, Zanni M. Early diagnosis of pancreatic cancer: What strategies to avoid a foretold catastrophe. World J Gastroenterol 2022; 28(31): 4235-4248
URL: https://www.wjgnet.com/1007-9327/full/v28/i31/4235.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i31.4235