Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures

Figure 3 Receiver operating characteristic curves to discriminate Crohn’s disease, ulcerative colitis, and healthy controls. A: Receiver operating characteristic (ROC) curve for Crohn’s disease (CD) vs healthy controls. Area under the curve (AUC) values of novel anti-flagellin antibodies (HP_0115, CK_LafA, CK_LafA.1, VC_flaD, VC_flaB, VC_flaE, VC_flaA) and anti-non-flagellin antibodies (BVU_0562, SP_1992, PMI_RS06815, SF_Lpp) was 0.73 and 0.75, respectively. The AUC value obtained with a combination of novel anti-flagellin and anti-non-flagellin antibodies was 0.81; B: ROC curve for ulcerative colitis (UC) vs healthy controls. The AUC value obtained with a combination of 7 markers was 0.87; C: ROC curve for CD vs UC. The AUC value obtained with a combination of 7 markers was 0.82.