Cumulative incidence and risk factors for pouch adenomas associated with familial adenomatous polyposis following restorative proctocolectomy

Table 2 Clinical characteristics of study patients according to presence of pouch adenomas

Characteristic	Presence of pouch adenomas (n = 24)	Absence of pouch adenomas (n = 71)	P value
Age at time of IPAA [yr, median (IQR)]	29 (20-40)	32 (26-41)	0.10
Sex (male), n (%)	16 (66.7)	36 (50.7)	0.17
No. of colorectal polyps [n, median (IQR)]	700 (325-1000)	250 (110-500)	0.001
Colorectal polyps < 1000, n (%)	16 (66.7)	64 (90.1)	0.006
Colorectal polyps ≥ 1000, n (%)	8 (33.3)	7 (9.9)
Time interval after IPAA [mo, median (IQR)]	142 (106-199)	116 (91-175)	0.01
Mucosectomy, n (%)	19 (79.2)	53 (74.6)	0.66
Gastric polyps, n (%)	19 (79.2)	51 (71.8)	0.49
Gastric polyp burden, n (%)			0.31
< 20	13 (54.2)	41 (57.7)
20-49	0	11 (15.5)
≥ 50	6 (25.0)	0
Duodenal adenomas, n (%)	16 (66.7)	30 (42.3)	0.039
Spigelman stage, n (%)			0.30
I	6 (37.5)	18 (60.0)
II	6 (37.5)	6 (20)
III	4 (25.0)	6 (20)
Desmoid tumor, n (%)	4 (16.7)	19 (26.8)	0.32
NSAIDs use, n (%)	1 (4.2)	14 (19.7)	0.07
Colorectal cancer, n (%)	9 (37.5)	34 (47.9)	0.38

IPAA: Ileal pouch anal anastomosis; NSAIDs: Nonsteroidal anti-inflammatory drugs; IQR: Interquartile range.