Salivary Fusobacterium nucleatum serves as a potential diagnostic biomarker for gastric cancer

Table 3 Diagnostic performance of Fusobacterium nucleatum, carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, ferritin, and sialic acid for gastric cancer

Index	AUC	Cut-off value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Fn	0.813	67.58 copies/μL	73.33	82.14	81.48	74.19
CEA	0.620	5 ng/mL	55.00	69.64	66.00	59.09
CA19-9	0.570	69.2 pg/mL	26.67	86.61	68.09	52.43
CA72-4	0.541	6.9 U/mL	67.50	44.64	56.64	56.18
Ferritin	0.648	400 ng/mL	51.67	23.21	41.89	30.95
Sialic acid	0.693	75.4 mg/dL	60.83	70.54	68.87	62.70

AUC: Area under curve; PPV: Positive predictive value; NPV: Negative predictive value; Fn: Fusobacterium nucleatum; CEA: Carcinoembryonic antigen; CA19-9: Carbohydrate antigen 19-9; CA72-4: Carbohydrate antigen 72-4.