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©The Author(s) 2022.
World J Gastroenterol. Aug 14, 2022; 28(30): 4102-4119
Published online Aug 14, 2022. doi: 10.3748/wjg.v28.i30.4102
Published online Aug 14, 2022. doi: 10.3748/wjg.v28.i30.4102
Table 1 Demographic and clinical characteristics of patients with inflammatory bowel disease in 1999-2020
| Total (n = 3610) | CD (n = 2208) | UC (n = 1402) | P value | |
| Male sex, n (%) | 1666 (46.2) | 935 (42.3) | 731 (52.1) | < 0.0001 |
| Median age of onset (IQR), yr | 31.0 (23.0-45.0) | 27.0 (21.0-37.0) | 42.0 (30.0-54.0) | < 0.0001 |
| Median age at diagnosis (IQR), yr | 33.0 (25.0-48.0) | 29.0 (23.0-39.0) | 45.0 (32.0-56.0) | < 0.0001 |
| Median interval from onset to diagnosis (IQR), mo | 12.2 (2.4-36.5) | 12.4 (3.7-36.7) | 6.17 (1.2-26.4) | < 0.0001 |
| Median duration of follow-up (IQR), yr | 1.6 (0.3-3.8) | 2.0 (0.8-3.9) | 0.7 (0.1-3.2) | < 0.0001 |
| Smoking status at diagnosis, n (%) | < 0.0001 | |||
| Non-smoker | 2860 (79.2) | 1828 (82.8) | 1032 (73.6) | |
| Current smoker | 356 (9.9) | 198 (9.0) | 158 (11.3) | |
| Former smoker | 233 (6.4) | 114 (5.2) | 119 (8.5) | |
| Unknown | 161 (4.5) | 68 (3.0) | 93 (6.6) | |
| Region of urbanization, n (%) | 0.7918 | |||
| Rural | 1607 (44.5) | 991 (44.9) | 616 (43.9) | |
| Urban | 1959 (54.3) | 1189 (53.8) | 770 (54.9) | |
| Unknown | 44 (1.2) | 28 (1.3) | 16 (1.2) | |
| Occupation, n (%) | < 0.0001 | |||
| Unemployed | 495 (13.7) | 316 (14.3) | 179 (12.8) | |
| Employed | 1851 (51.3) | 1227 (55.6) | 624 (44.5) | |
| Student | 377 (10.5) | 334 (15.1) | 43 (3.1) | |
| Retire | 258 (7.1) | 95 (4.3) | 163 (11.6) | |
| Unknown | 629 (17.4) | 236 (10.7) | 393 (28.0) | |
| BMI category at diagnosis, n (%) | < 0.0001 | |||
| Normal | 1014 (28.1) | 812 (36.8) | 202 (14.4) | |
| Underweight | 1524 (42.2) | 912 (41.3) | 612 (43.7) | |
| Overweight + Obese | 379 (10.5) | 183 (8.3) | 196 (14.0) | |
| Unknown | 691 (19.2) | 300 (13.6) | 391 (27.9) | |
| Disease location, n (%) | ||||
| L1—ileal location | - | 626 (28.4) | - | |
| L2—colon location | 224 (10.2) | |||
| L3—ileocolon location | 1142 (51.8) | |||
| L4—including upper GI location | 211 (9.6) | |||
| E1—proctitis | - | 201 (14.3) | ||
| E2—left-sided | 458 (32.7) | |||
| E3—extensive colitis | 660 (47.1) | |||
| Unknown | 83 (5.9) | |||
| Disease activity (CDAI/Mayo), n (%) | ||||
| Remission | 122 (3.4) | 100 (4.5) | 22 (1.6) | |
| Mild | 719 (19.9) | 417 (18.9) | 302 (21.5) | |
| Moderate | 1683 (46.6) | 1156 (52.4) | 527 (37.6) | |
| Severe | 440 (12.2) | 188 (8.5) | 252 (18.0) | |
| Unknown | 646 (17.9) | 347 (15.7) | 299 (21.3) | |
| Disease behavior, n (%) | ||||
| B1—inflammatory disease | - | 1175 (53.3) | - | |
| B2—stricturing disease | 690 (31.3) | |||
| B3—penetrating disease | 338 (15.4) | |||
| Perianal involvement, n (%) | ||||
| Fistula | - | 772 (35.0) | - | |
| Abscess | 392 (17.8) | |||
| Fissure | 38 (1.7) | |||
| Extraintestinal manifestations, n (%) | 464 (12.9) | 357 (16.2) | 107 (7.6) | < 0.0001 |
| Family history of IBD, n (%) | 27 (0.7) | 20 (0.9) | 7 (0.5) | 0.1671 |
| History of gastrointestinal surgery, n (%) | 594 (16.5) | 524 (23.7) | 70 (5.0) | < 0.0001 |
| History of perianal surgery, n (%) | 471 (13.0) | 471 (21.3) | 0 (0.0) | < 0.0001 |
| Medication use before diagnosis (≤ 6 mo), n (%) | 908 (25.2) | 440 (19.9) | 468 (33.4) | < 0.0001 |
- Citation: Yao LY, Shao BL, Tian F, Ye M, Li YQ, Wang XL, Wang L, Yang SQ, Lv XP, Jia Y, Wang XH, Zhang XQ, Wei YL, Cao Q. Trends in medication use and treatment patterns in Chinese patients with inflammatory bowel disease. World J Gastroenterol 2022; 28(30): 4102-4119
- URL: https://www.wjgnet.com/1007-9327/full/v28/i30/4102.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i30.4102