Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures

Table 3 Subgroup analysis of inflammatory bowel disease patients

Classification	Comparison	Number of antibodies with		Two sample proportion test
		OR > 1	OR < 1
Disease behavior: B1: non-stricturing, non-penetrating; B2: stricturing; B3: penetrating	B1 vs B2 (P < 0.05)	0	32	P < 0.001
	B2 vs B3 (P < 0.05)	0	19	P < 0.001
	B1 vs B3 (P < 0.05)	2	41	P < 0.001
Disease location: L1: ileal; L2: colonic; L3: ileocolonic	L1 vs L2 (P < 0.05)	0	38	P < 0.001
	L2 vs L3 (P < 0.05)	9	5	P = 0.131
	L1 vs L3 (P < 0.05)	5	16	P < 0.001
Disease extent: E2: left sided UC; E3: extensive UC	E2 vs E3 (P < 0.05)	11	39	P < 0.001
Surgery in CD patients	No vs Yes (P < 0.05)	6	25	P < 0.001

For each comparison, the number of antibodies with significant difference in prevalence between two classifications were counted based on odds ratio (OR) > 1 and OR < 1. The difference in total number of antibodies for each comparison were computed using two sample proportion test. CD: Crohn’s disease; UC: Ulcerative colitis; OR: Odds ratio.