Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures

Table 2 Sensitivities of validated IgG antibodies comparing Crohn’s disease and ulcerative colitis with healthy controls in the discovery, validation, and the entire set at 96% specificity

		Antigen	Protein name	Organism	Discovery	Validation	Entire
Crohn's disease	Bacteria	HP_0115	Flagellin B	H. pylori	28	48	38
		BVU_0562	Uncharacterized protein	B. vulgatus	26	22	25
		CK_LafA	Lateral flagellin	C. koseri	20	22	21
		CK_LafA.1	Lateral flagellin	C. koseri	16	26	24
		A4-Fla2	Flagellin	L. bacterium A4	40	54	47
		PMI_RS06815	Hypothetical protein	P. mirabilis	14	16	15
		VC_flaD	Flagellin	V. cholerae	24	18	19
		VC_flaB	Flagellin	V. cholerae	28	22	24
		VC_flaE	Flagellin	V. cholerae	26	28	23
		VC_flaA	Flagellin	V. cholerae	20	22	21
		SF_Lpp	Outer membrane lipoprotein	S. flexneri	14	18	14
		SP_1992	Cell wall surface anchor	S. pneumoniae	20	16	18
	Virus	BILF2	Glycoprotein BILF2	Human herpesvirus 4	18	18	18
Ulcerative colitis	Bacteria	CK_flgG	Flagellar basal-body rod protein	C. koseri	14	16	15
		A4-Fla2	Flagellin	L. bacterium A4	22	16	18
	Virus	BVRF2	Capsid scaffolding protein	Human herpesvirus 4	14	16	14
		UL139	Membrane glycoprotein UL139	Human herpesvirus 5	14	20	17