Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats

doi:10.3748/wjg.v28.i3.348

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2022; 28(3): 348-364
Published online Jan 21, 2022. doi: 10.3748/wjg.v28.i3.348

Table 3 Micronucleus test in the bone marrow of the rats that underwent bile duct ligation, treated or not with melatonin

Groups	MNPCE¹ in 2000 PCE	Ratio PCE/NCE²
CO	4.0 ± 1.5	1.1 ± 0.2
CO + MLT	3.3 ± 1.0	1.1 ± 0.4
BDL	7.8 ± 1.3^a	1.0 ± 0.6
BDL + MLT	6.8 ± 1.9	0.9 ± 0.5

¹MNPCE: Micronuclei in polychromatic erythrocytes.

²PCE/NCE ratio: Proportion of polychromatic erythrocytes/normochromatic erythrocytes.

^aP < 0.01: Significant increase in the bile duct ligation group in relation to the control and CO + melatonin groups. (Analysis of variance, Tukey test).

CO: Control; MLT: Melatonin; BDL: Bile duct ligation.

Citation: Colares JR, Hartmann RM, Schemitt EG, Fonseca SRB, Brasil MS, Picada JN, Dias AS, Bueno AF, Marroni CA, Marroni NP. Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats. World J Gastroenterol 2022; 28(3): 348-364
URL: https://www.wjgnet.com/1007-9327/full/v28/i3/348.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i3.348