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©The Author(s) 2022.
World J Gastroenterol. Jan 21, 2022; 28(3): 310-331
Published online Jan 21, 2022. doi: 10.3748/wjg.v28.i3.310
Published online Jan 21, 2022. doi: 10.3748/wjg.v28.i3.310
Table 2 Characteristics of non-alcoholic fatty liver disease-associated hepatocellular carcinoma based on studies including cohorts of non-alcoholic fatty liver disease-associated hepatocellular carcinoma patients
| Ref. | Year/Country | Total NAFLD-HCC patients | Prevalence of NAFLD-HCC without cirrhosis, n (%) | Fibrosis stage of non-cirrhotic NAFLD-HCC patients, n (%) | Tumor characteristics in cirrhotic vs non-cirrhotic NAFLD-HCC patients (differentiation) |
| Piscaglia et al[24] | 2015/Italy | 145 patients | 67 (46) | F0 = 3 (18.75); F1-F2 = 2 (12.5); F3 = 11 (68.75) (Undefined fibrosis stage in 51 patients) | NSD in tumor size |
| Leung et al[46] | 2015/Australia | 54 patients | 8 (15) | F0 = 2 (33.3); F1-F2 = 4 (66.7) (Undefined fibrosis stage in 2 patients) | ↑ tumor diameter in non-cirrhotic (4.7 cm) vs cirrhotic (3.2 cm) (P = 0.041). NSD in median number of tumors in non-cirrhotic (2) vs cirrhotic (1). NSD in HCC differentiation |
| Kodama et al[47] | 2019/Japan | 104 patients | 58 (55.8) | F0 = 6 (5.8); F1 = 11 (10.6); F2 = 18 (17.3); F3 = 23 (22.1) | NSD in HCC differentiation |
| Mohamad et al[48] | 2015/United States of America | 83 patients | 36 (43.4) | F0 = 18 (55.9); F1 = 6 (17.6); F2 = 3 (8.8); F3 = 6 (17.6) | ↑ incidence of single nodules in non-cirrhotic (80.6%) vs cirrhotic (52.2%) (P < 0.05). ↑ proportion of large nodule size (> 5 cm) in non-cirrhotic (77.8%) vs cirrhotic (10.6%) (P < 0.05). NSD in HCC differentiation |
| Tobari et al[49] | 2020/Japan | 119 patients | 48 (40.3) | F0-F1 = 12 (32.4); F2 = 17 (46); F3 = 8 (21.6) (Undefined fibrosis stage in 11 patients) | ↑ tumor size in non-cirrhotic (46 mm) vs cirrhotic (28 mm) (P < 0.01). NSD in HCC differentiation. NSD in median number of tumors |
| Yasui et al[25] | 2011/Japan | 87 patients | 43 (49.4) | F1 = 10 (23.2); F2 = 15 (34.9); F3 = 18 (41.9) | NA |
| Thompson[50] | 2018/United States | 48 patients | 26 (54) | F0 = 10 (38.5); F1 = 8 (30.8); F2 = 5 (19.2); F3 = 1 (3.8) | ↓ tumor size in non-cirrhotic (3.3 cm) vs cirrhotic (5.7 cm) (P < 0.01). NSD in HCC differentiation |
| Cotrim et al[51] | 2016/Brazil | 110 patients | 20 (48.5) | F0 = 2 (12.5); F1-3 = 14 (87.5) | NA |
| Iannaccone et al[52] | 2007/France | 22 patients | 16 (72.3) | F0 = 7 (31.8); F1-3 = 9 (40.9) | NA |
- Citation: Chrysavgis L, Giannakodimos I, Diamantopoulou P, Cholongitas E. Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link. World J Gastroenterol 2022; 28(3): 310-331
- URL: https://www.wjgnet.com/1007-9327/full/v28/i3/310.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i3.310