Involvement of nitrergic neurons in colonic motility in a rat model of ulcerative colitis

Figure 8 Comparison of isolated colonic circular muscle contraction tension. A-D: Contraction amplitude of the colonic circular muscle of CG (A), EG1 (B), EG2 (C), and EG3 (D) rats; E: Comparison of the contraction tension of the rat colonic circular muscle among the four groups: CG (1.46 ± 0.06 g), EG1 (2.12 ± 0.49 g), EG2 (2.87 ± 0.04 g), and EG3 (1.72 ± 0.04 g). All differences were statistically significant between EG groups and CG group (^aP < 0.0001) and between EG2-3 groups and EG1 group (^bP < 0.0001). CG: Control group; UC: Ulcerative colitis; NOS: Nitric oxide synthase; L-NMMA: NG-monomethyl-L-arginine monoacetate; EG1: UC group; EG2: UC + NOS agonist TP508TFA group; EG3: UC + NOS inhibitor L-NMMA group; CM: Circular muscle.