Involvement of nitrergic neurons in colonic motility in a rat model of ulcerative colitis

Figure 7 Comparison of isolated colonic longitudinal muscle contraction tension. A-D: Contraction amplitude of the colonic longitudinal muscle of CG (A), EG1 (B), EG2 (C), and EG3 (D) rats; E: Comparison of the contraction tension of the colonic longitudinal muscle among rats from the four groups: CG (0.69 ± 0.02 g), EG1 (1.4 2 ± 0.02 g), EG2 (2.24 ± 0.07 g), and EG3 (1.01 ± 0.02 g). All differences were statistically significant between EG groups and CG group (^aP < 0.0001) and between EG2-3 groups and EG1 group (^bP < 0.001). CG: Control group; UC: Ulcerative colitis; NOS: Nitric oxide synthase; L-NMMA: NG-monomethyl-L-arginine monoacetate; EG1: UC group; EG2: UC + NOS agonist TP508TFA group; EG3: UC + NOS inhibitor L-NMMA group; LM: Longitudinal muscle.