High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1

Figure 6 Long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 acted on the miR-15a-5p/activating transcription factor 6 axis to activate the endoplasmic reticulum stress signaling pathway. ND-MAT-Exos, HFD-MAT-Exos, HFD-MAT-Exos + shMALAT1, and HFD-MAT-Exos + miR-15a-5p mimic are labelled as 1, 2, 3, and 4 groups, respectively. A: The expression level of activating transcription factor 6 in colon tissue; B: The expression level of endoplasmic reticulum stress related proteins in colon tissue detected by Western blotting; C: The expression level of interleukin (IL)-β, tumor necrosis factor α, IL-6 in the colon tissue detected by enzyme linked immunosorbent assay. ATF-6: Activating transcription factor 6; IL: Interleukin; TNF-α: Tumor necrosis factor α. ^aP < 0.05, ^bP < 0.01.