High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1

Figure 5 Mesenteric adipose tissue derived exosomes of high-fat diet-fed mice aggravate 2,4,6-trinitrobe-nzenesulfonic acid solution-induced colitis, reversed by shMALAT1 and miR-15a-5p mimic. A: Body weight change trend of mice in each group; B: Colon length of mice in each group; ND-MAT-Exos, HFD-MAT-Exos, HFD-MAT-Exos + shMALAT1, and HFD-MAT-Exos + miR-15a-5p mimic are labelled as A, B, C, and D groups, respectively; C: Colon image of mice in each group; D: Disease activity index of mice in each group; E: Histological damage score of colon tissue, ND-MAT-Exos, HFD-MAT-Exos, HFD-MAT-Exos + shMALAT1, and HFD-MAT-Exos + miR-15a-5p mimic are labelled as A, B, C, and D groups, respectively; F: Hematoxylin and eosin staining images of colon tissue. HFD: High-fat diet; ND: Normal diet; MAT-Exos: Mesenteric adipose tissue derived exosomes; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1. ^aP < 0.05, ^bP < 0.01.