Clinical challenge for gastroenterologists–Gastrointestinal manifestations of systemic mastocytosis: A comprehensive review

Figure 3 Frustules of hepatic parenchyma with substantially preserved structure, with trabeculae with 2-cell spinnerets with no significant steatosis, but focal balloon-like degeneration associated with biliary stasis phenomena. A: Biliary spaces with preserved ducts, with ductular regeneration and bilio-hepatocyte metaplasia (hematoxylin-eosin, × 4); B: Some phenomena of hepatitis with aggression of the biliary epithelium are observed (hematoxylin-eosin, × 20). Portal spaces enlarged due to the presence of mixed inflammatory infiltrates, mainly consisting of T lymphocytes (CD3 +) with initial fibrotic expansion and formation of porto-portal bridges; C: In this context, scattered CD117 +, tryptase + cells (× 20) referable to mast cells.