Clinical challenge for gastroenterologists–Gastrointestinal manifestations of systemic mastocytosis: A comprehensive review

Figure 2 Spectrum of histologic findings in patients with intestinal involvement of systemic mastocytosis. A: A mild initial finding with mast cells arranged in sheets and micro aggregates (hematoxylin-eosin, × 10). A heavy eosinophil infiltrate frequently dominates the picture. Crypt architectural distortion, without any other evidence of inflammatory bowel disease. Scattered lymphocytes and plasma cells often accompanied the mast cell and eosinophil infiltrates; B-C: The mast cells show expression of c-kit (B; CD117, × 2) and tryptase (C; × 10); D: CD25 positive cells in a clearcut and spread duodenal mastocytosis (CD25, × 10).