Radiomics for differentiating tumor deposits from lymph node metastasis in rectal cancer

Table 4 Subgroup analyses of the models in single-positive patients

	Rad-score 1			Rad-score 2			P value
Subgroups	AUC	SEN (%)	SPE (%)	AUC	SEN (%)	SPE (%)
nCRT
With (n = 77)	0.740 (95%CI: 0.628-0.833)	73.5%	74.4%	0.897 (95%CI: 0.806-0.954)	73.5%	90.7%	0.014
Without (n = 127)	0.753 (95%CI: 0.668-0.825)	60%	86.1%	0.957 (95%CI: 0.905-0.985)	89.1%	93.1%	< 0.001
Location
Mid-low (n = 139)	0.782 (95%CI: 0.704-0.848)	75.4%	62.2%	0.931 (95%CI: 0.875-0.967)	86.2%	82.4%	< 0.001
High (n = 65)	0.643 (95%CI: 0.515-0.758)	54.2%	73.2%	0.941 (95%CI: 0.853-0.984)	83.3%	85.4%	< 0.001
Number of TDs	1-2 (n = 50)	≥ 3 (n = 39)	P = 0.838	1-2 (n = 50)	≥ 3 (n = 39)	P = 0.309
Value	0.64 ± 0.24	0.65 ± 0.22		0.83 ± 0.22	0.77 ± 0.26

Rad-score 1: Rad-score of the main tumor; Rad-score 2: Rad-score of the largest peritumoral nodule; TDs: Tumor deposits; AUC: Area under the curve; SEN: Sensitivity; SPE: Specificity; nCRT: Neoadjuvant chemoradiotherapy.