Radiomics for differentiating tumor deposits from lymph node metastasis in rectal cancer

Table 3 Comparisons of the models in the training, validation, and mixed groups

	Training set				Validation set				Mixed group
	AUC	SEN	SPE	P value	AUC	SEN	SPE	P value	SEN	SPE	Accuracy
Rad-score 1	0.768 (95%CI: 0.695-0.830)	66.2%	70.7%	< 0.001	0.700 (95%CI: 0.537-0.833)	77.8%	47.8%	0.032	-	-	-
Combined model	0.955 (95%CI: 0.910-0.981)	83.1%	88.0%	0.134	0.930 (95%CI: 0.805-0.986)	94.4%	82.6%	0.594	66.6%	73.3%	70.0%
Rad-score 2	0.940 (95%CI: 0.892-0.971)	83.1%	84.8%		0.918 (95%CI: 0.789-0.981)	83.3%	82.6%		73.3%	66.6%	70.0%

The mixed group consisted of 15 double-positive (TDs⁺LNM⁺) and 15 single-positive (11 TDs⁺LNM^- and 4 LNM⁺TDs^-) patients. P value: compared with Rad-score 2 by DeLong’s test. Rad-score 1: Rad-score of the main tumor; Rad-score 2: Rad-score of the largest peritumoral nodule; TDs: Tumor deposits; LNM: Lymph node metastasis; AUC: Area under the curve; SEN: Sensitivity; SPE: Specificity.