Optimal timing of biliary drainage based on the severity of acute cholangitis: A single-center retrospective cohort study

Table 4 Univariate and multivariate analysis of predictors of mortality, and relationship of mortality with the timing of drainage for each predictor

Predictors (n = 1305)	Univariate analysis		Multivariate analysis		Mortality to the timing of drainage
	OR (95%CI)	P value	OR (95%CI)	P value	< 12 h	> 12 h or absence	P value	< 24 h	> 24 h or absence	P value	< 48 h	> 48 h or absence	P value
Neurological dysfunction	8.377 (4.384-16.007)	< 0.001	5.32 (2.373-11.931)	< 0.001	0/22	18/104	0.041	3/42	15/84	0.175	5/51	13/75	0.304
Respiratory dysfunction	2.886 (1.491-5.497)	0.003	2.541 (1.189-5.43)	0.016	1/44	14/183	0.314	4/91	11/136	0.414	6/117	9/110	0.428
Renal dysfunction	11.043 (5.402-22.573)	< 0.001	6.356 (2.623-15.397)	< 0.001	1/15	12/49	0.269	1/28	12/36	0.004	1/31	12/33	0.001
Cardiovascular dysfunction	11.569 (5.078-26.357)	< 0.001	4.021 (1.361-11.88)	0.012	0/7	9/32	0.169	2/16	7/23	0.262	2/18	7/21	0.139
Hematological dysfunction	2.611 (1.253-5.441)	0.02	N/A		2/37	8/104	1	3/61	7/88	0.527	3/74	7/75	0.327
Hepatic dysfunction	5.263 (2.484-11.152)	< 0.001	N/A		0/15	10/68	0.196	1/30	9/53	0.086	1/39	9/44	0.016
Age (≥ 75 yr)	1.432 (0.765-2.680)	0.261	N/A		2/88	21/531	0.759	4/196	19/423	0.172	7/267	16/352	0.284
Temperature (≥ 39 ℃)	0.390 (0.093-1.631)	0.197	N/A		0/43	2/106	1	1/75	1/74	1	1/85	1/64	1
WBC (> 12000/mm3, < 4000/mm3)	1.962 (1.043-3.688)	0.036	N/A		1/107	23/445	0.063	4/207	20/342	0.031	6/278	18/275	0.012
T-Bil (≥ 5 mg/dL)	1.711 (0.865-3.385)	0.123	N/A		3/143	26/626	0.333	5/292	24/477	0.019	8/407	21/362	0.007
Albumin (< STD*0.7)	10.715 (5.147-22.303)	< 0.001	5.655 (2.398-13.335)	< 0.001	0/8	12/51	0.188	0/15	12/44	0.026	1/24	11/35	0.018
Lactate (≥ 2 mmol/L)	1.450 (0.766-2.747)	0.254	N/A		0/105	16/298	0.016	2/186	14/217	0.008	4/227	12/176	0.018
Malignant obstruction	5.495 (2.924-10.325)	< 0.001	7.522 (3.504-16.149)	< 0.001	1/26	21/216	0.483	2/59	20/183	0.116	3/101	19/141	0.006
CCI (> 3)	4.080 (2.153-7.7340)	< 0.001	N/A		2/57	23/318	0.397	4/127	21/248	0.052	6/177	19/198	0.021

WBC: White blood cell count; T-Bil: Total bilirubin; STD: Lower limit of normal value; CCI: Charlton Comorbidity Index; OR: Odds ratio; CI: Confidence interval; N/A: Not applicable.