Optimal timing of biliary drainage based on the severity of acute cholangitis: A single-center retrospective cohort study

doi:10.3748/wjg.v28.i29.3934

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Aug 7, 2022 (publication date) through Nov 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Aug 7, 2022; 28(29): 3934-3945
Published online Aug 7, 2022. doi: 10.3748/wjg.v28.i29.3934

Table 1 Characteristics data for all patients

Characteristics, n (%)	Total (n = 1305)	Grade I (n = 433)	Grade II (n = 405)	Grade III (n = 467)	P value
Age (yr)-median (IQR)	74 (63-82)	66 (59-72.5)	79 (69-84)	77 (66-83)	< 0.001
Male, n (%)	783 (60)	276 (63.7)	240 (59.3)	267 (57.2)	0.123
CCI- median (IQR)	2 (1-4)	2 (1-3)	2 (1-4)	3 (1-5)	< 0.001
Etiology, n (%)					< 0.001
Choledocholithiasis	906 (69.4)	315 (72.7)	252 (62.2)	339 (72.6)
Malignant obstruction	242 (18.5)	73 (16.9)	97 (24.0)	72 (15.4)
Benign stenosis	94 (7.2)	27 (6.2)	42 (10.4)	25 (5.4)
Others	63 (4.8)	18 (4.2)	14 (3.5)	31 (6.6)
Biliary drainage, n (%)	915 (70.1)	302 (69.7)	306 (75.6)	307 (65.7)	0.006
LOS (d)-median (IQR)	11 (8-14)	11 (8-14)	11 (7.5-14)	12 (7-15)	0.110
Hospitalization cost (CNY)-median (IQR)	38784.37 (22744.31-53278.63)	36536.36 (20851.37-47274.77)	38308.33 (23452.14-52847.29)	41832.19 (23355.98-58145.52)	< 0.001
IHM, n (%)	41 (3.1)	1 (0.2)	7 (1.7)	33 (7.1)	< 0.001
Survival time of dead (d)-median (IQR)	8 (3-23.5)	9	23 (13-46)	6 (3-17)	0.024
Organ dysfunction
Neurological dysfunction	126	0	0	126	< 0.001
Respiratory dysfunction	227	0	0	227	< 0.001
Renal dysfunction	64	0	0	64	< 0.001
Cardiovascular dysfunction	39	0	0	39	< 0.001
Hematological dysfunction	149	0	0	149	< 0.001
Hepatic dysfunction	83	0	0	83	< 0.001
Temperature (℃)-median (IQR)	37.0 (36.6-38)	36.8 (36.6-37.8)	37 (36.6-38.25)	37.2 (36.6-38.3)	0.001
Laboratory values
WBC (/mm³)-median (IQR)	10560 (7705-14305)	9120 (7160-11165)	12700 (8897-18441)	11140 (7870-15810)	< 0.001
T-Bil (mg/dL)-median (IQR)	99.81 (62.43-155.76)	69.28 (49.625-120.975)	121.74 (88.97-184.41)	1041.2 (67.74-156.31)	< 0.001
Albumin (g/L)-median (IQR)	35.4 (31.2-39.2)	37.5 (34.2-40.4)	34.9 (30.8-38.1)	33.6 (29.2-37.8)	< 0.001
Lactate (mmol/L)-median (IQR)	2.15 (1.6-3.4)	1.8 (1.4-2.7)	2.1 (1.5-2.8)	2.4 (1.7-4.1)	< 0.001

IQR: Interquartile range; CCI: Charlton Comorbidity Index; LOS: Length of stay; CNY: Chinese Yuan; IHM: In-hospital mortality; WBC: White blood cell count; T-Bil: Total bilirubin.

Citation: Lu ZQ, Zhang HY, Su CF, Xing YY, Wang GX, Li CS. Optimal timing of biliary drainage based on the severity of acute cholangitis: A single-center retrospective cohort study. World J Gastroenterol 2022; 28(29): 3934-3945
URL: https://www.wjgnet.com/1007-9327/full/v28/i29/3934.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i29.3934