Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma

Table 5 Fractions of characteristics (feature) selected during internal cross-validation for evaluating the two-marker combination performance

Feature	Fraction selected in cross-validation
All HCC vs CLD
PIVKA-II	1.00
hsa-miR-21-5p	0.86
hsa-miR-320d	0.10
hsa-miR-339-3p	0.02
hsa-miR-320a	0.01
hsa-miR-423-5p	0.00
Early HCC vs CLD
PIVKA-II	1.00
hsa-miR-21-5p	0.60
hsa-miR-320d	0.18
hsa-miR-652-3p	0.16
hsa-miR-339-3p	0.02
hsa-miR-221-3p	0.01
hsa-miR-30b-5p	0.01
hsa-miR-10b-5p	0.00
hsa-miR-15b-5p	0.00
Early HCC vs cirrhosis
PIVKA-II	1.00
hsa-miR-652-3p	0.64
hsa-miR-221-3p	0.26
hsa-miR-21-5p	0.05
hsa-miR-423-5p	0.04
hsa-miR-320a	0.01
hsa-miR-339-3p	0.01
hsa-miR-320d	0.00

CLD: Chronic liver disease; HCC: Hepatocellular carcinoma; PIVKA-II: Protein induced by vitamin K absence/antagonist-II; miR: MicroRNA.