Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma

Table 4 Multivariate analysis of real-time quantitative PCR results for comparison

Marker	AUC	Specificity at 90% sensitivity	Comparison
PIVKA-II	0.83	34	All HCC vs CLD
PIVKA-II + miRNAs	0.87	48
PIVKA-II	0.70	15	Early HCC vs CLD
PIVKA-II + miRNAs	0.74	29
PIVKA-II	0.64	12	Early HCC vs cirrhosis
PIVKA-II + miRNAs	0.71	42

Area under the curve and specificity at 90% sensitivity for Protein induced by vitamin K absence/antagonist-II alone and in combination with the 26 selected miRNAs, resulting from the logistic regression model. AUC: Area under the curve; CLD: Chronic liver disease; HCC: Hepatocellular carcinoma; miRNA: MicroRNA; PIVKA-II: Protein induced by vitamin K absence/antagonist-II.